Stimulus for renin angiotensin system?

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In the discussion, the primary focus is on understanding the stimulus for renin secretion during a hemorrhage. Two potential stimuli are considered: the decrease in renal perfusion pressure detected by the afferent arteriole and the decrease in sodium chloride detected by the macula densa. It is clarified that a decrease in renal perfusion leads to less sodium being perceived by the macula densa, which is crucial for the regulation of the Renin-Angiotensin-Aldosterone System (RAAS). Additionally, the complexity of the RAAS is highlighted, noting that various feedback mechanisms, including atrial stretch receptors and beta-1 adrenergic receptors, can influence renin levels. This underscores the interconnected nature of renal function and systemic responses to changes in blood volume and pressure.
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Hello everyone,

I have to write a simple essay about this,I know what to write but I'm stuck with the stimulus so can't start the essay. My textbook is so vague. I want to know the stimulus in a haemorrhage.

1. Is it the decrease in renal perfusion pressure detected by afferent arteriole that secretes renin.
2. Or decrease in sodium chloride deteced by the macula densa that stimulates it.

Thanks :smile:
 
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sameeralord said:
Hello everyone,

I have to write a simple essay about this,I know what to write but I'm stuck with the stimulus so can't start the essay. My textbook is so vague. I want to know the stimulus in a haemorrhage.

1. Is it the decrease in renal perfusion pressure detected by afferent arteriole that secretes renin.
2. Or decrease in sodium chloride deteced by the macula densa that stimulates it.

Thanks :smile:

If you have a decrease in renal perfusion, what does the macula densa "see". Does it see more or less sodium? That is how the kidney regulates RAAS.

You should note though, that the RAAS system is complex and requires lots of feed back modifiers. Atrial stretch receptors (barroreceptors) can also alter circulating renin levels.
 
have a look at beta 1 receptors in the autonomics section of any pharm text - and tie that in with the baroreceptor response bobz mentioned
 

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