Da rules.
If you are going to use radio for telemetry, you need to stay in the amateur band which requires at least a basic license. You can use GPS with cell phone without any special license but you need cell coverage over the landing zone. You probably won't be in cell range above 5000 feet. FAA requires that you have a payload of less than 6lb for unmanned balloons. Here is a
graph of the temperatures your payload will experience. If you use handwarmers, remember they will stop working where the air is thin! You should be OK for the ascent since the air in the payload is expanding and forcing, or keeping at bay, the cold air outside. Descent sucks... that cold air into your package! That's when things get iffy. It seems to me that you could put your electronics into a plastic enclosure with a one way valve like they use for coffee. You'll probably need coffee as well so you can pick up that plastic bag with one-way valve at the grocery. You can calculate an
estimate for your balloon's flight plan here. http://sua.faa.gov/sua/special.do?selected=2&sua=conus both on ascent and decent. If you are near any airbases, review their "MOA" (good Google term).
How will you know how much helium to add to your balloon? Add too little and it may not pop until it drifts waaaay downrange. Add too much and it comes down too early.
Hmmmm.