Understanding Bombay Blood Group and its Compatibility for Blood Donation

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An individual with the genotype I^oI^o and hh is classified as having the Bombay blood group, not type O. The Bombay blood group lacks the H antigen, which is present in type O blood. Consequently, a person with the Bombay blood group can donate blood to anyone but can only receive blood from others with the same Bombay phenotype due to the presence of anti-H antibodies. This creates a compatibility issue, as they cannot accept blood from O-type individuals, despite the latter being a universal donor for other blood types. Confusion arises from differing sources regarding the presence of H antibodies; while some assert they exist, others suggest that individuals with the Bombay phenotype do not express the H antigen, leading to potential reactions if mixed with H antigen-containing blood. This highlights the complexity of blood group compatibility and the importance of accurate information in blood transfusions.
Suraj M
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If an individual has a genotype##I^oI^o## and ##hh## is he considered to be O or bombay blood group?
Also i read that a person with bombay blood group can donate blood to anyone but can accept only from a person of his blood group, why can't he/she accept blood from O-ve?( is there a H antibody?)
 
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that answers my second question, but contradicts my teachers statement. :(
Thank you anyway,
Anyone for my first question?
 
Suraj M said:
If an individual has a genotype##I^oI^o## and ##hh## is he considered to be O or bombay blood group?

Would that individual be able to accept blood donations from an O-type individual or only from h/h-type individuals?
 
he can take from O, probably, but if there are H antibodies then , no!
My teacher said that There is no H antibody , but wikipedia says that there are..
 
Here's a more definitive reference which says there is an H antigen:

http://www.ncbi.nlm.nih.gov/books/NBK2268/

As I read the article more, it says people may have a deficit of the H so I'm looking for a better article to explain it.

I think your teacher meant to say that people with this blood type don't express the H antigen.
 
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I don't feel like trusting that article they say that parabombay blood group have a genotype HH, andthat they have anti-H, which i don't think exists naturally.
I asked another teacher, he said that though there might not be secifically H antibodies, but there will be some reaction, when blood(Hh/HH) is mixed with bombay blood group blood.
 
For your first question, yes, it is Bombay blood group since O has H not h.
There are anti-H antibodies according to my teacher who swears by Wikipedia :P
 
you have some interesting Bio questions :)
 
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