Op-amps can amplify both AC and DC signals, with input voltages for V+ and V- typically requiring DC supplies. The input pins V+IN and V-IN can accept either AC or DC signals, depending on the application. It is crucial to understand the common mode voltage range specified in the datasheet, which indicates the optimal input voltage levels for performance. A high common mode rejection ratio ensures that the op-amp amplifies only the difference between the input signals rather than their average. For best performance, inputs should be maintained within the specified voltage limits in the datasheet.