The electrostatic Coulomb force of a charge Q_1 at the origin and Q_2 at position \vec{x}=r \vec{e}_r is given by
\vec{F}=k_e \frac{Q_1 Q_2}{r^2} \vec{e}_r.
This is an innocent looking formula, but physically it has a lot of content.
First of all it's on the very foundation of electromagnetic phenomena. It tells you that there is an intrinsic quantity of matter, called electric charge, i.e., a piece of matter is not only characterized by its mass but also by its electric charge. Then Coulomb's Law tells you that the force betweent two charged point particles is proportional to the charges of these particles and that it depends on distance between the particles by an inverse-square law. Last but not least it acts along the straight line connecting the two charges.
In other words the Coulomb law defines how to measure charges and also includes the observed behavior of the electrostatic with distance.
On the other hand, there is no more content to it than this, and we have not even mentioned the constant k_e in the explanation of the physical meaning of the symbols in this formula. This tells you that in principle you do not need this constant at all, and indeed in the good old days of the Gaussian system of units, one has just set k_{e}^{(\text{Gauss})}=1.
This choice is, however not very convenient from a practical point of view since then charge has funny units, when in terms of the basis units of mechanics (in the Gaussian system, these were centimetres, grams, and seconds for length, mass, and time).
Thus, later one has taken a forth basis unit into the game, when one extends mechanics to the realm of electromagnetic phenomeno. In the modern system of units, the SI (Systeme international de poids et messures), this is the Ampere as the unit of electric current (Charge per time flowing through a given area). The price to pay for that is to introduce the factor k_e=1/(4 \pi \epsilon_0). I guess, this will be the units you'll be using most probably in your studies.
If it comes to theoretical high-energy physics, you'll stumble over still another system of units, which is very close to Gauss units, the socalled Heaviside-Lorentz system, which boils down to set k_e=1/(4 \pi). The reason for this choice is that then the fundamental equations governing all electromagnetic phenomena, Maxwell's equations, become most simple: There are no "artificial" unit-conversion factors as \epsilon_0 as in the SI and also no factors 4 \pi in these fundamental equations.
This answers also your final questions: The 4 \pi in the denominator make Maxwell's equations simpler, and the \epsilon_0 is needed for conversion of charge units to mechanical units in Coulomb's Law of the electrostatic force. You can, in principle, measure \epsilon_0 using Colomb's Law. Then you have to use the very definition of the Ampere, given by the magnetostatic force between two straight current-conducting wires, to charge bodies with a well quantified amount of electric charge (measured in the unit 1 \text{C}=1 \text{A} \text{s}.