Multiple harmonics contribute to the timbre of sound produced by instruments like strings and tubes, making it challenging to isolate just the fundamental frequency. Techniques such as isolating harmonics on a guitar can emphasize specific frequencies while minimizing others. The discussion highlights that harmonics and overtones significantly define an instrument's sound quality, which varies based on the instrument's design and playing technique. The concept of sound quality is subjective, often linked to the characteristics of the sound rather than a strict good or bad classification. For visual representations of harmonics, resources like frequency spectrum analyses and videos demonstrating waveforms can provide clarity on this topic.