Yes. We have a set R in a plane xy and a set R* in a plane uv.
We have functions f(x, y) and F(u, v) and the variables have this relations:
u = u(x, y) and v = v(x,y).
x = x(u, v) and y = y(u,v).
These functions u, v, x, y are inyective.
In Apostol' Calculus (vol.2), in the preliminaries to the proof of the Change of Variable theorem for Multiple Integrals, Apostol states this (I am translating from spanish to english):
"For the proof we suppose that the functions x and y have continuous second partial derivatives and that the jacobian nevers goes null in R*. The J(u, v) is always positive or always negative. The meaning of the sign of J(u,v) is thath when a point (x, y) describes the boundary of R in counterclockwise sense, the image point (u, v) describes the boundary of R* in the same sense if J(u,v) es positive and in contrary sense if J(u,v) is negative.