What is the effect of thiazide diuretics on GFR?

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Diuretics, specifically thiazides and loop diuretics, have different effects on glomerular filtration rate (GFR). Loop diuretics are noted to have no effect on GFR, as stated in Katzung's 12th edition, while the impact of thiazides on GFR is not explicitly mentioned. Thiazides are typically not prescribed when GFR is below 30 ml/min, with the exception of metolazone, which can be used in such cases. In contrast, loop diuretics are often utilized in patients with heart failure who have compromised renal function, indicating their broader applicability in managing fluid overload despite reduced GFR. The discussion highlights the need for clarity on thiazide use in relation to GFR and the rationale behind the differing clinical practices for these diuretics.
Manish7
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Having a little query that what is the effect of diuretics (both thiazides and loops)
on GFR ?
Athough katzung 12th edi. says loops _ no effect on gfr, but it is silent on thiazides ?
no thiazides are given when GFR <30ml/min except metolazone while loop diuretics are given in
heart failure with compromised renal functions(failure). why??
 
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