There are so many applications that any list I could think of would be certain to be incomplete. So let me just pick one really common example from physics. We all know the simple distance-speed-time relationships, distance = speed x time for example.
Great formula but, it only works when speed is a constant! This is extremely limiting and means we can't handle any type problem involving accelerated motion. Fortunately calculus let us salvage that equation and make it much more general.
Say that we are trying to apply that equation, x = vt, (where "x" is distance), except the velocity "v" is not constant. Since the equation "dist = speed x time" only applies for constant velocity, it looks like we're stuck? Imagine however that we divide up time into lots of really small slices, say for example one microsecond increments*. Now over such a small time increment any changes in velocity will be very small so we can take "v" as approximately constant within any given time slice. That is, we can now use our formula despite the fact we have accelerated motion.
The new problem however, is that we are only finding the distance traveled one microsecond at a time, and we have to add up all of those one microsecond slices to find the total distance traveled. This is what integration does. We write the distance traveled in one time slice "dx" as,
dx = v \, dt
Where "dt" is the small time slice and "dx" is the small distance traveled. This of course integrates to,
x = \int v \, dt
So we've taken a simple speed time formula that only works for constant speed, and made it into a much more general integral equation that works for velocity as an arbitrary function of time. Physics and Engineering are absolutely full of applications very like this.
* The example of one microsecond is just to help you visualize it. Of course differentiation and integration are defined in terms of the limit as this time slice goes to zero.