If there's just one wire, then there's cylindrical symmetry.
That tells you immediately that any force on a proton or electron due to the wire it's in could not point in a radial direction. If it pointed in one direction, which one? You could rotate the wire around its axis and nothing would change, but the force would have to rotate to be consistent with where it was before. That makes no sense - so any force must be in the line of the wire.
But in the line of the wire, the thing that matters most is the charged particles nearby - and there are as many of them infront of any given proton or electron as there are behind. That means that you can make the same argument as above. Flip the wire end-for-end and nothing changes, but any force would have to flip too to be consistent.
This second step is obviously an approximation, since the wire is not of infinite length and a proton or electron will typically be nearer one end than the other. But it's not a bad approximation as long as you think of the wire as "long".
Recognising what symmetries there are in a situation is a very useful trick for short-circuiting complex calculations. In this case, it means that when you are thinking about a proton or electron in one of the wires, you cn ignore the other protons and electrons in that same wire, and only worry about fields from the other wire.