it very simply because of the quantum numbers they carry ! For example, the first observed (to be confirmed!) pentaquark is the Theta+. This particle has positive strangeness, therefore one is forced to introduce an anti-strange quark (strange antiquark) (you know what I mean, right?) in the valence structure.
This in turn implies that this pentaquark is NOT just a regular 3-quark structure plus a vacuum fluctuation of meson orbiting around, but rather a resonant structure involving 5 quarks.