Why Can't WBC Attack Naegleria Fowleri?

[Navin]

I had a question as to why WBC can't attack Naegleria fowleri when it attacks the brain ?

 

[.Scott]

I had a question as to why WBC can't attack Naegleria fowleri when it attacks the brain ?

White Blood Cells are not allowed across the Blood/Brain barrier.

https://en.wikipedia.org/wiki/Blood–brain_barrier

 

[Navin]

White Blood Cells are not allowed across the Blood/Brain barrier.

https://en.wikipedia.org/wiki/Blood–brain_barrier

...oh.
Huh..thats highly convinient !
Thanks so much

 

[Laroxe]

Who says they can't? its a common organism that rarely causes disease but quite a lot of people have antibodies to the organism suggesting exposure is quite common. The brain is what's referred to as immune privileged, because a sever inflammatory response could cause more damage than whatever caused it it is to some extent isolated from the rest of the bodies systems and has its own specialist immune cells. This is a fairly large mobile amoeba which is attracted to neuro-chemicals, it enters the body through the nose and tracks into the brain. Its no great surprise that phagocytes have difficulty containing it, this happens in a lot of infections but we do mount an antibody response that appears to control the amoeba. There may be all sorts of reasons why this antibody response fails in a small number of people, a guess might be the transit time from nose to brain but there are all sorts of possibilities. Apparently around 80% of cases are in males and around 66% in children but this might simply indicate risky behaviour. Its difficult to diagnose and despite having effective drugs few victims survive.

 

[Navin]

Who says they can't? its a common organism that rarely causes disease but quite a lot of people have antibodies to the organism suggesting exposure is quite common. The brain is what's referred to as immune privileged, because a sever inflammatory response could cause more damage than whatever caused it it is to some extent isolated from the rest of the bodies systems and has its own specialist immune cells. This is a fairly large mobile amoeba which is attracted to neuro-chemicals, it enters the body through the nose and tracks into the brain. Its no great surprise that phagocytes have difficulty containing it, this happens in a lot of infections but we do mount an antibody response that appears to control the amoeba. There may be all sorts of reasons why this antibody response fails in a small number of people, a guess might be the transit time from nose to brain but there are all sorts of possibilities. Apparently around 80% of cases are in males and around 66% in children but this might simply indicate risky behaviour. Its difficult to diagnose and despite having effective drugs few victims survive.

So i can safely say that even in the brain ,the anti bodies act against it ?

 

[Laroxe]

Whether safely is the right word is debatable or even if the antibodies act in the brain or prevent the organism reaching the brain but for antibodies to develop it suggests that our immune system will have been exposed to the organism for some time and so the money must be on the infection being present but asymptomatic. Its always difficult to get good information about rare conditions.
This seems to give a good overview.
https://www.webmd.com/brain/brain-eating-amoeba#1

 

[Navin]

Whether safely is the right word is debatable or even if the antibodies act in the brain or prevent the organism reaching the brain but for antibodies to develop it suggests that our immune system will have been exposed to the organism for some time and so the money must be on the infection being present but asymptomatic. Its always difficult to get good information about rare conditions.
This seems to give a good overview.
https://www.webmd.com/brain/brain-eating-amoeba#1

I aldredy saw that site but i felt it didnt give like in dept information.Im actually doing a project on Naeglearisis and N Fowleri. I almost finished it but wanted deeper info on it.Like how does the amoeba "feeding scoop " work when it feeds on the brain and how do the drugs actually act on it and stuff

I would be extremely obliged if u could tell me more !

 

[Laroxe]

The organism normally feeds on bacteria so its logical to assume that they will engage in phagocytosis it is also suggested that it produces two proteases -- enzymes that dissolve protein, so they liquefy the brain.

Some light reading
https://web.stanford.edu/group/parasites/ParaSites2010/Katherine_Fero/FeroNaegleriafowleri.htm

which has a number of other links to follow up

and some drugs to look up;
Amphotericin B was the standard of treatment. Lately this has been combined with Miltefosine and along with high doses of steroids has resulted in two patient recoveries.

 

[Navin]

The organism normally feeds on bacteria so its logical to assume that they will engage in phagocytosis it is also suggested that it produces two proteases -- enzymes that dissolve protein, so they liquefy the brain.

Some light reading
https://web.stanford.edu/group/parasites/ParaSites2010/Katherine_Fero/FeroNaegleriafowleri.htm

which has a number of other links to follow up

and some drugs to look up;
Amphotericin B was the standard of treatment. Lately this has been combined with Miltefosine and along with high doses of steroids has resulted in two patient recoveries.

Thank you so much man ! I really am grateful for this !
The link was beautiful !
More so i completely missed out writing about Amphotericin B.i had just given it a small mention.

Ob the other hand i dedicated a couple of pages on Miltefosin.
By anychance i if you know how Miltefossin acts on N fowleri i would love to know.I have written about the history and uses of miltefossin and about the Leishmania thingie but no where is it mentioned as HOW miltefossin effects N. Fowleri. Like what does the drug do ? Affect the Amoeboid ETC ? Affect the protein synthesis by binding to ribosome ?

If you have any info id love to know

 

[Laroxe]

Have a look at this and again there are associated links.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604384/

 

[Navin]

Th

Have a look at this and again there are associated links.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604384/

thank you so much ! It was extremely detailed and i got all that i wanted !