- #1
foldedelephants
- 3
- 0
The title should say: why does antagonising D2 receptors reduce positive schizophrenic symptoms?
It doesn't make sense to me. If positive schizophrenic symptoms are caused by too much dopamine signalling in the mesolimbic system, and D2 receptors hyperpolarise the post synaptic neuron when activated, how does antagonising the D2 receptor reduce activity within the mesolimbic system?
It doesn't make sense to me. If positive schizophrenic symptoms are caused by too much dopamine signalling in the mesolimbic system, and D2 receptors hyperpolarise the post synaptic neuron when activated, how does antagonising the D2 receptor reduce activity within the mesolimbic system?