Why is intrinsic pathway not activated in vivo?

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The discussion centers on the activation of the extrinsic and intrinsic pathways of coagulation. The extrinsic pathway, primarily activated by tissue factor III and VII during trauma, is identified as the major pathway for clotting. In contrast, the intrinsic pathway, activated by surface collagen through Factor XII, is considered less critical and does not need to be activated for effective clotting. It is clarified that individuals deficient in intrinsic pathway clotting factors may still experience adequate clotting due to the dominance of the extrinsic pathway in the coagulation process.
sameeralord
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Hello everyone,

The book says invivo extrinsic pathway is the one that gets activated, but intrinsic pathway is activated by surface collagen, so it must be activated as well. Both must be activated right, also if a person is deficient of intrinsic pathway clotting factors, would they have no problems with clotting because extrinsic pathway is the major one involved. Thanks :smile:
 
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sameeralord said:
Hello everyone,

The book says invivo extrinsic pathway is the one that gets activated, but intrinsic pathway is activated by surface collagen, so it must be activated as well. Both must be activated right, also if a person is deficient of intrinsic pathway clotting factors, would they have no problems with clotting because extrinsic pathway is the major one involved. Thanks :smile:

Yes. The extrinsic (tissue factor III+VII) is the major pathway and is activated by trauma. The intrinsic pathway (Factor XII) is surface activated and is less important. It need not be activated for an adequate clotting cascade.
 
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