The discussion centers on the size of the human brain compared to a walnut, exploring evolutionary factors that influence brain size and intelligence. It highlights that mammal brains have adapted to fit within skull constraints by becoming crumpled, which increases surface area and allows for higher cognitive functions. The conversation notes that larger brains do not necessarily equate to higher intelligence, as many primates have comparable or larger brains without being considered more intelligent than humans. Limitations on skull size are linked to pelvic and birth canal constraints, suggesting evolutionary trade-offs. The potential for future brain size evolution is also mentioned, with the possibility of changes in skull shape accommodating larger brains. The discussion emphasizes that the complexity of brain structure, particularly cortical folds, may be more significant than sheer size in determining cognitive abilities.