Within ourselves, does blood have an expiry date?

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Discussion Overview

The discussion revolves around the lifespan of blood components within the human body, particularly focusing on red blood cells and the processes involved in the removal of "garbage blood." Participants explore the mechanisms of blood cell turnover, waste processing, and the roles of various organs in these processes.

Discussion Character

  • Exploratory
  • Technical explanation
  • Conceptual clarification

Main Points Raised

  • Some participants propose that blood has a limited lifespan, particularly red blood cells, which they suggest last about three months before being expelled from the body.
  • One participant mentions that the expulsion of red blood cells contributes to the color of feces, linking this to the breakdown of hemoglobin.
  • Another participant discusses the role of the kidneys in filtering plasma and excreting waste products, noting the selective reabsorption processes that maintain homeostasis.
  • There is a mention of various blood products, such as lymphocytes and macrophages, and a question about how these materials transition from the blood to the gut.
  • A later reply outlines two primary routes for waste elimination from the body: through the kidneys and the liver, detailing the processes involved in breaking down cellular debris and reusing components.
  • One participant expresses amazement at the extent of current knowledge regarding these processes, contrasting it with the unknowns that still exist.

Areas of Agreement / Disagreement

Participants generally agree on the limited lifespan of red blood cells and the roles of the kidneys and liver in processing blood components. However, there are questions and uncertainties regarding the specifics of how various materials are processed and eliminated from the body, indicating that the discussion remains unresolved in certain areas.

Contextual Notes

Some assumptions about the mechanisms of blood processing and the specific roles of different organs are not fully explored, and there are unresolved questions regarding the transition of materials from blood to the gut.

rowkem
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I would assume that blood, within us, is only good for so long but, I could be wrong. Also, if it does become "bad", where does it go? How do we get rid of "garbage blood"?
 
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Red blood cells last about 3 months and then die. They are expelled in the feces. That is partly what gives feces its characteristic colour.

(BTW, their limited lifespan is of great use to Diabetics. Sugar buillds up in the Hemoglobin of RBCs in direct proportion to its levels in the body. As these RBCs are replenished, their concentration reflects a history of the body's sugar levels. By doing a test callled HbA1c, doctors can get a very good idea of how a patient's blood sugars have been doing over the previous three months. This is of much greater use than any number of on-the-spot tests.)
 
The plasma is circulated through the kidneys (25% of the blood is directed there), corresponding to 130 liters/day. Molecules smaller than (approximately) albumin enter the ultrafiltrate and pass through nephrons, where material is selectively reabsorbed to maintain homeostasis, and waste products (small molecules like urea, sodium, etc) excreted.

That's a good question about other blood products- lymphocytes, macrophages, neutrophils, all kinds of cells, cell fragments, proteins, lipoproteins... circulate. I don't know how material passes from the blood to the gut. That's actually a really good question...
 
I took this over to a colleague and discussed.

Ok- there are two main routes of things out of the body, either via the kidney or via the liver (bile acids). Cellular debris, from lysed cells or whatever, is processed in the liver and broken back down into the elemental components- the same process happens, to some degree, in each cell (proteosomes, lysosomes, endosomes..) and the components re-used as much as possible.

Fat soluable wastes in particular, are put into the bile and excreted into the ileum and moves along the gut. Hemoglobin is broken down in the liver and re-used; the 'life cycle' of iron in the body is marginally understood.

What's amazing is not how little we know, it's how much we *do* know.
 

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