Why myeloid-erythroid ration is 4:1 while more RBC's in blood?

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The discussion centers on the contrasting ratios of myeloid and erythroid cells in the bone marrow and circulation. In the bone marrow, the typical ratio is approximately 4:1, with four myeloid cells for every erythroid cell. However, in circulation, red blood cells (RBCs) vastly outnumber white blood cells (WBCs), with a ratio of nearly 1000:1. This discrepancy raises questions about the underlying reasons. One explanation offered is the lifespan difference between these cells; erythrocytes can circulate for about 120 days, while leukocytes generally last only 3-4 days. This lifespan difference contributes to the perception of imbalance in cell numbers. Additionally, it is suggested that the bone marrow may maintain a reserve of myelopoietic cells for emergencies. A correction in the ratio calculation indicates that the actual ratio may be closer to 2:1.
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In the bone marrow, the normal ratio of myeloid and erythroid series cells is 4:1. So, for every erythroid cell, there are four myeloid cells, which gives
But in the circulation, there are almost 1000 times more RBC's than total WBC's ( which also includes non-myeloid WBC's, such as lymphocytes. )

Why is it so?
 
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tarekatpf said:
In the bone marrow, the normal ratio of myeloid and erythroid series cells is 4:1. So, for every erythroid cell, there are four myeloid cells, which gives
But in the circulation, there are almost 1000 times more RBC's than total WBC's ( which also includes non-myeloid WBC's, such as lymphocytes. )

Why is it so?

http://en.wikipedia.org/wiki/Bone_marrow

I'm not sure it is so. Myelopoietic cells constitute 56.6% of parenchymal cells while erythropoietic cells constitute 25.6% of such cells. Erythrocytes circulate for about 120 days while leukocytes circulate for about 3-4 days. This may explain part of the perceived imbalance. No teleologic explanation is required for the rest of the perceived imbalance, but it might be that the bone marrow holds a reserve of myelopoietic cells for emergencies.

EDIT: Allowing for the possibility of an error in my addition, it's still clear the ratio is closer to 2:1.
 
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