When a 100N force acts on a 1kg mass, the acceleration is calculated using F=ma, resulting in an acceleration of 100 meters per second squared. However, applying this principle to buoyancy, particularly for bubbles, complicates the situation, as it can lead to unrealistic predictions of unlimited acceleration. The discussion highlights the need for a more nuanced understanding of forces in fluid dynamics, suggesting Stokes' Equations as a better framework for analyzing terminal velocity in falling spheres. The conversation emphasizes that not all scenarios can be simplified to basic physics equations due to the influence of nonconservative forces. Overall, the complexities of real-world physics require careful consideration beyond straightforward applications of F=ma.