The upcoming ACS conference in Washington, D.C., is generating interest, particularly regarding notable speakers and their topics. Key highlights include presentations from prominent chemists such as Dennis Curran on fluorous chemistry, Erik Sorensen on enantioselective total synthesis, and K. Barry Sharpless discussing azides and alkynes. Other significant topics include DNA damage repair by Greg Verdine and complex catalytic reactions by Donna Blackmond. The technical program has been released, allowing attendees to identify speakers relevant to their fields. The ACS hosts two major conferences annually, with the previous one held in San Diego. Attendees recommend the experience, especially for students, as it offers a wealth of knowledge and networking opportunities, despite some concerns about institutional support for attendance.