Fermat's Little Theorem and Wilson's Theorem are historically significant in number theory, providing foundational insights despite their inefficiency for large numbers. While they are not practical for finding primes in large datasets, they serve as valuable educational tools for understanding number theory concepts. These theorems are effective for simpler, homework-style problems, making them accessible for learners. Their real-life applications vary based on the context, as they may not be the most efficient methods for large-scale computations. Overall, their relevance is context-dependent, highlighting their role in the evolution of mathematical understanding.