Are platelets required for blood clotting?

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In blood clotting disorders, the increased clotting time is attributed to issues in the coagulation cascade, while platelet disorders do not affect clotting time because platelets primarily function in the initial phase of hemostasis, forming a plug. Platelet activation is triggered by von Willebrand factor released from damaged blood vessels. The process of clot formation involves both primary hemostasis, where platelets aggregate, and secondary hemostasis, where a fibrin mesh stabilizes the clot. Prothrombin time (INR) specifically assesses the extrinsic coagulation pathway, indicating that both phases of hemostasis are essential for creating a stable blood clot. Red blood cells and platelets do indeed become trapped in the fibrin mesh, contributing to the overall structure of the blood clot.
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In blood clotting disorders, clotting time is increased, but when there is plalete disorder clotting time is not affected. What is the reason for that. Aren't platelets required for blood clotting. Also when a fibrous mesh is formed, do red blood cells and platelets get stuck in it. Is it why blood clots. Thanks :smile:
 
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sameeralord said:
In blood clotting disorders, clotting time is increased, but when there is plalete disorder clotting time is not affected. What is the reason for that. Aren't platelets required for blood clotting. Also when a fibrous mesh is formed, do red blood cells and platelets get stuck in it. Is it why blood clots. Thanks :smile:

Platelets are activated in primary hemostasis to form an initial plug which becomes enmeshed in the fibrin clot as the coagulation cascade proceeds (secondary hemostasis). Platelet activation is initiated with the release of von Willibrand factor from damaged vessel walls.

Prothrombin time (INR) measures only the extrinsic coagulation pathway in vitro and is only meaningful relative to a standard control time. Both primary and secondary hemostasis are necessary to form a stable clot as far as I know.
 
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