Are there known side-effects of myostatin in meat and body building?

[Golgot]

Hi all,

Does anyone know where I can get some concrete information on the original experiments with mice which had their myostatin gene knocked out (I believe, altho myostatin "blocking" seems to be the technique that is now prefered) ...and here's the important bit...they gained 2-3 times the normal muscle mass, but also became notably unaggressive/timid. I have several sources containing circumstantial evidence, but none of the original investigators seem to have documented these findings.

Can anyone help?

Also, does anyone know whether myostatin products have really found their way into the meat industries and body building communities (plus do you know of any known or potential side-effects involved).

Thanks for any help

Tom

 

[Ygggdrasil]

This reference appears to the be the original paper describing the myostatin knockout mouse (myostatin was previously named GDF-8): https://www.ncbi.nlm.nih.gov/pubmed/9139826

The paper does not mention any behavioral phenotypes, though that would not be evidence that such phenotypes do not exist.