Medical Are there only two neurotransmitters in the PNS?

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The discussion clarifies that the primary neurotransmitters in the peripheral nervous system (PNS) are acetylcholine and norepinephrine, with acetylcholine being the predominant one. It addresses the misconception regarding epinephrine, stating that it is not considered a neurotransmitter in the PNS. Instead, epinephrine primarily functions as a hormone synthesized in the adrenal gland, with only minor activity as a neurotransmitter in the central nervous system (CNS).
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I read that the only 2 neurotrasmitters in the PNS are acetylcholine and norepinephrine. Acetylcholine being the main one. That can't be right can it? What about epinephrine?
 
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DrFishNips said:
I read that the only 2 neurotrasmitters in the PNS are acetylcholine and norepinephrine. Acetylcholine being the main one. That can't be right can it? What about epinephrine?

Epinephrine is not a neurotransmitter in the PNS. Its only activity as a neurotransmitter is a minor one in the CNS. Its primarily synthesized in the adrenal gland and its main systemic activity is as a hormone.
 
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