The discussion centers on the determination of Avogadro's number, 6.022E23, which represents the number of atoms in 12 grams of carbon. While the number is named after Amedeo Avogadro, he did not calculate this value himself; his work established that atoms combine in whole numbers. The actual determination of Avogadro's number occurred about a century later, with significant contributions from Jean Perrin, who received the Nobel Prize in the 1920s for his work in this area. Various methods have been employed to calculate the Avogadro constant, reflecting advancements in scientific techniques over time.