Starting with assembly language can be challenging for those without programming knowledge, as it is highly optimized for specific applications and requires a deeper understanding of computing concepts. High-level programming languages, such as PERL, Visual Basic, JavaScript, and C/C++, are generally more accessible and practical for beginners, offering easier syntax and constructs like conditional statements. Learning a high-level language first can provide a solid foundation that will be beneficial when transitioning to assembly later. Resources for learning these languages are abundant online, with many tutorials and examples available. Focusing on a specific application or goal can help guide the choice of language to learn.