To calculate the number density of a fuel composition with 75 wt% ThO2 and 25 wt% UO2, where U enrichment is 19.5 w%, use the formula N = (Rho * NA) / A, where Rho is the density in g/cm^3, NA is Avogadro's number, and A is the atomic weight in g. The composite number density can be determined by weighing the contributions of each nuclide based on their proportions in the mixture. This includes calculating the number densities for Thorium and the two isotopes of Uranium, U-235 and U-238. Additionally, the discussion suggests that the inquiry may relate to finding the macroscopic cross-section, which involves multiplying the number density by the microscopic cross-section measured in barns. Understanding these calculations is essential for accurate nuclear fuel analysis.