To calculate the temperature loss when mixing two water streams, use the weighted average of their temperatures based on their flow rates. The smaller stream flows at 2,400 gph at 85°F, while the larger stream flows at 37,000 gph at 105°F. A mass and energy balance equation is necessary to determine the final temperature, which involves calculating the enthalpy of each stream. Ensure that the inlet temperatures are below the saturation temperature for accurate results. Once the enthalpy is calculated, refer to a steam table or database like REFPROP to find the corresponding exit temperature.