Medical Chloramphenicol & Aplastic Anemia

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Ophthalmic chloramphenicol drops are commonly used in Western medicine for treating bacterial conjunctivitis. While there are isolated reports of aplastic anemia associated with these eye drops, the risk is considered very low, estimated at less than 1 in 224,716 prescriptions. Some sources suggest that the connection between chloramphenicol eye drops and aplastic anemia is not well established. In Mexico, chloramphenicol is also used prophylactically in newborns. Overall, the safety of ophthalmic chloramphenicol remains a topic of discussion, with no definitive conclusions drawn regarding its association with aplastic anemia.
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Is opthalmic chloramphenicol drops proven to be safe or not? Does it promote aplastic anemia or is it the oral version only? What's the mechanism of interaction that is so far discovered?
 
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rodsika said:
Is opthalmic chloramphenicol drops proven to be safe or not? Does it promote aplastic anemia or is it the oral version only? What's the mechanism of interaction that is so far discovered?

This is a summation of what's known:

Wikipedia said:
Eye dropsIn the West, chloramphenicol is still widely used in topical preparations (ointments and eye drops) for the treatment of bacterial conjunctivitis. Isolated cases report of aplastic anaemia following chloramphenicol eyedrops exist, but the risk is estimated to be less than 1 in 224,716 prescriptions.[9] Note. http://www.patient.co.uk/showdoc/40025037/ suggests that the link between chloramphenicol eye drops and aplastic anemia is "not well founded". In Mexico, this is the treatment used prophylactically in newborns.

I don't believe there is anything more definitive.
 

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