Coevolution of spatial and synaptic distribution of neurons in C elegans

AI Thread Summary
The discussion centers on the analysis of neural network motifs in C. elegans as presented in the original article by Milo et al. They propose that certain network motifs are overrepresented due to evolutionary pressures, comparing them to a random distribution. Artzy-Randrup et al. challenge this by arguing that the study fails to account for a true null hypothesis, particularly neglecting the influence of spatial distribution among neurons, which could affect network formation. In response, Milo defends the significance of spatial distribution, asserting that it is an integral part of understanding the evolutionary selection processes that lead to the observed overrepresentation of motifs. The conversation raises questions about the implications of spatial distribution on the study's conclusions and whether it introduces complexities that could alter interpretations of the data. There is also a call for updates on the current state of research in this area, indicating a desire for ongoing dialogue and exploration of these findings.
Pythagorean
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1) Original Article:
http://www.sciencemag.org/content/298/5594/824.short

2) Comment on Article:
http://www.sciencemag.org/content/305/5687/1107.3.full

3) Rebuttal:
http://www.sciencemag.org/content/305/5687/1107.4.full

Summary of above:

1) Original authors (Milo, et al) create a random distribution of neural network motifs and compare it to the distribution of networks in C. elegans. Any distribution that is significantly over represented compared to the random set is declared significant (result of evolutionary pressure).

2) Artzy-Randrup, et al say 'well, you didn't control for a true null-hypothesis, you didn't factor out spatial distribution. neurons form networks with other neurons that are spatially close.'

3) The rebuttal from Milo is that the spatial distribution of the neurons is a significant aspect of the results of the selection that results in this overrepresentation.

Just curious what the PF Biology expert opinions are. I tend to side with Milo here, but I'm naive. To me, knowing spatial distribution is a priori knowledge, just like any other. If we have a mechanism for WHY a nertwork motif is over-represented (i.e. spatial distribution) that that just gives us more insight, it doesn't negate the study.

What do you think? Is there a spandrelly story to spatial distribution of neurons that I'm not considering?
 
Biology news on Phys.org
The links still appear to be okay. @Pythagorean are there updates that should be here?
 
Wow, reallly going back now. My brain cells have completely turned over since this post, I have no idea of the current state of this research.
 
We'll lock it and note that it lacks current work.
 

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