Confused with resting membrane potential

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SUMMARY

The discussion centers on the confusion surrounding the resting membrane potential of nerve cells, specifically regarding the role of potassium ions (K+) and their movement across the membrane. It is established that at rest, the nerve cell membrane is primarily permeable to potassium, which moves out of the cell due to its concentration gradient through non-gated potassium channels. This movement creates a negative charge inside the cell, leading to an electrical gradient that opposes further movement of K+. The net electrochemical gradient ultimately drives K+ out of the cell, despite the equilibrium potential suggesting no net movement. The participant seeks clarification on the relative concentrations of ions during resting and action potentials.

PREREQUISITES
  • Understanding of resting membrane potential in neurons
  • Knowledge of ion channels, specifically non-gated potassium channels
  • Familiarity with electrochemical gradients and equilibrium potential
  • Basic concepts of action potentials in nerve cells
NEXT STEPS
  • Research the Nernst equation for calculating equilibrium potentials of ions
  • Study the role of sodium (Na+) and potassium (K+) during action potentials
  • Explore the mechanisms of ion channel gating and permeability changes
  • Investigate the impact of various ion concentrations on resting membrane potential
USEFUL FOR

Students of neuroscience, biology educators, and anyone interested in the physiological mechanisms of nerve cell function and action potentials.

Misr
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hello world long time no see..actually I've been very confused with this resting membrane potential I've sooo many questions but i'll only ask one question for now .at rest the membrane of nerve cell is permeable to potassium , potassium goes outside the cell along its concentration gradient through non gated potassium channel leaving negative charges behind so the elwctrical gradient of potassium opposes its concentration gradient ...okay okay let's sum up... Concentrstion gradient drives potaddium outside the cell...electrical gradient drives potassium inside thr cell so what's my problem? My problem is that it is written in my textbook that the net electrochemical gradient tends to force potassium ions out of the cell..how?it's also written that each ion tries to reach an equilibrium potential where the flow of ion in one direction is balanced by its flow in the opposite direction...so its supposed that chemical gradient of potassium is balanced by electrical gradient so no net movement of potassium ions but this doesn't happen because it contradicts with the fact that the inside of the membrane is negative relative to the outside so what actually happens that potaddium is driven out of the cell because of the net electrochemical gradient. Can you understand my problem that makes mr suffer and think of it all the time?could you explain this for me pleade?can you write the relative concentrations of ions on both sides of membrane during rest and also during action potential?thanks guys
 
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