COVID Covid Variant Omicron (B.1.1.529)

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A new Covid-19 variant, B.1.1.529, has emerged in Botswana and South Africa, raising concerns due to its high number of mutations, particularly on the spike protein, which could affect vaccine efficacy. Scientists warn that this variant may evade monoclonal antibodies, potentially leading to new outbreaks as countries reopen borders. The UK has responded by banning flights from several African nations and reintroducing quarantine measures for travelers. The World Health Organization is set to evaluate the variant, which may be classified as a variant of concern, and could be named Omicron. The situation remains fluid as researchers continue to monitor the variant's spread and impact on public health.
  • #51
First, Moderna has already tested a higher dose booster of mRNA-1273 (100 µg) in healthy adults.
...
Second, Moderna is already studying two multi-valent booster candidates in the clinic that were designed to anticipate mutations such as those that have emerged in the Omicron variant. The first candidate (mRNA-1273.211) includes several mutations present in the Omicron variant that were also present in the Beta variant of concern1. The Company has completed dosing in a potentially pivotal safety and immunogenicity study of mRNA-1273.211 at the 50 µg (N=300) and 100 µg (N=584) dose levels. A second multi-valent candidate (mRNA-1273.213) includes many of the mutations present in the Omicron variant that were also present in the Beta and Delta variants2. The Company has completed dosing at the 100 µg (N=584) dose level and also plans to explore the 50 µg dose level in approximately 584 participants. Moderna will rapidly expand testing of sera from completed and ongoing multi-valent booster studies to determine if these multi-valent candidates are able to provide superior neutralizing protection against Omicron.

Third, Moderna will rapidly advance an Omicron-specific booster candidate (mRNA-1273.529).
...
Source:
https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-strategy-address-omicron-b11529-sars-cov-2/

Related Moderna tests:
This is a study to evaluate the immunogenicity, safety, and reactogenicity of mRNA-1273.211, mRNA-1273, mRNA-1273.617.2, and mRNA-1273.213.
Source:
https://clinicaltrials.gov/ct2/show/study/NCT04927065

AstraZeneca tests the Covid-19-vaccine AZD2816 based on the gene of the Beta variant:
https://clinicaltrials.gov/ct2/show/NCT04973449

BionTech tests the Covid-19-vaccine BNT162b2SA based on the gene of the Beta variant:
https://clinicaltrials.gov/ct2/show/NCT04368728

BionTech tests the Covid-19-multivariant vaccine BNT162b2 (B.1.1.7 + B.1.617.2) based on the genes of the Alpha and Delta variants:
https://clinicaltrials.gov/ct2/show/NCT05004181
 
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  • #52
cmb said:
So the sooner the better we figure out if there is a good reason to seek particular steps to limit this particular variant, would you not agree?
You act as though there isn't a good reason to be highly concerned about this variant. There is a serious risk that we can deduce from its makeup. If the variant does turn out to evade vaccine induced immunity, then how many elderly and other people at higher risk will become suddenly vulnerable even though they've had the vaccine? Out of concern for those people, responsible/caring people should take the extra precautions, at least until we know it's safe. Remember slowing exponentiation growth is better done early. People need time to prepare.

At least people should be taking non-economy disturbing measures seriously. E.g. everyone who can breath sufficiently through one should be using n95, kn95, or kf94 masks when indoors in public.
 
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  • #53
Jarvis323 said:
You act as though there isn't a good reason to be highly concerned about this variant. There is a serious risk that we can deduce from its makeup. If the variant does turn out to evade vaccine induced immunity, then how many elderly and other people at higher risk will become suddenly vulnerable even though they've had the vaccine? Out of concern for those people, responsible/caring people should take the extra precautions, at least until we know it's safe. Remember slowing exponentiation growth is better done early. People need time to prepare.

At least people should be taking non-economy disturbing measures seriously. E.g. everyone who can breath sufficiently through one should be using n95, kn95, or kf94 masks when indoors in public.
You are misreading me, and I think the reason for that is that my view is balanced, neither over estimating risks nor underestimating risks. Most people are in one of those camps so I will always be perceived as 'in the other camp' by everyone!

Simply this; I am as concerned about over-reacting to this new variant as under-reacting to it. I do not fear for under-reactions at this time, that does not seem to be a concern given how people are reacting now.
 
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  • #54
cmb said:
You are misreading me, and I think the reason for that is that my view is balanced, neither over estimating risks nor underestimating risks. Most people are in one of those camps so I will always be perceived as 'in the other camp' by everyone!

Simply this; I am as concerned about over-reacting to this new variant as under-reacting to it. I do not fear for under-reactions at this time, that does not seem to be a concern given how people are reacting now.
For me, it's not a thing you just balance out in terms of how much fear, or lack of fear, that people should have. It's a thing you Pareto-optimize in terms of measures you take. You could be someone with almost no concern, and it still makes sense to wear an n95 mask in public. It's about minimizing risk, while also minimizing cost.
 
  • #55
Pfizer and Moderna are developing vaccines targeting Omicron.

https://www.businessinsider.com/pfizer-vaccine-update-100-days-omicron-variant-resistant-2021-11

"Pfizer and BioNTech have taken actions months ago to be able to adapt the mRNA vaccine within six weeks and ship initial batches within 100 days in the event of an escape variant," the company said in a statement.

Pfizer expects to know within two weeks whether the variant is resistant to its current vaccine, a company spokesperson told Reuters.

"We expect more data from the laboratory tests in two weeks at the latest. These data will provide more information about whether B.1.1.529 could be an escape variant that may require an adjustment of our vaccine if the variant spreads globally," the spokesperson said.

Moderna and Johnson & Johnson are also preparing to respond to the Omicron's possible threat.

Moderna on Friday said it plans to test a variant-specific booster in the event that its current vaccine is found to be ineffective against the Omicron.

https://www.npr.org/2021/11/27/1059534796/covid-19-vaccine-makers-combat-omicron-variant
Vaccine makers are already pivoting their efforts to combat the new variant: testing higher doses of booster shots, designing new boosters that anticipate strain mutations, and developing omicron-specific boosters.

In a statement sent to NPR, Moderna said it has been working on a comprehensive strategy to predict variants of concern since the beginning of 2021. One approach is to double the current booster from 50 to 100 micrograms. Secondly, the vaccine maker has been studying two booster vaccines that are designed to anticipate mutations like those found in the omicron variant. The company also said it will ramp up efforts to make a booster candidate that specifically targets omicron.
. . . .

Pfizer and BioNTech told Reuters that it expects more data about the omicron variant to be collected within two weeks. That information will help determine whether or not they need to modify their current vaccine. Pfizer and BioNTech said that a vaccine tailored for the omicron variant, if needed, could be ready to ship in approximately 100 days.

Johnson & Johnson said in a statement sent to NPR that it too is already testing its vaccine's efficacy against the new variant.

Pfizer and Moderna set to adapt to Omicron COVID variant
https://nypost.com/2021/11/27/vaccine-makers-set-to-adapt-for-omicron-covid-variant/I read an announcement that the governor of New York State has declared a health emergency due to the Omicron variant threat. I do not know what that means, i.e., what steps that state government plans to take. Ostensibly, some kind of mandate, e.g., 'wear a mask in public'?

https://www.wsj.com/articles/new-yo...ergency-to-combat-omicron-variant-11638039097
"Precautionary measure will allow hospitals to turn away patients seeking nonurgent care"

We'll have to watch for outbreaks of Omicron in regions near international airports.
 
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  • #56
valenumr said:
Another twitter thread (with cnn interview, sorry, it's not like there are a bunch of peer reviewed studies on the topic, and it's just hard to search on the internet, because it's everywhere):
Prof Peter Hotez MD PhD, who has been on the front lines fighting Covid-19 infections in Houston, has credibility. Hotez is Professor: Departments of Pediatrics and Molecular Virology & Microbiology Baylor College of Medicine Houston, Texas, and Dean of the National School of Tropical Medicine and Professor of Pediatrics and Molecular Virology & Microbiology at Baylor College of Medicine where he is also the Co-director of the Texas Children’s Center for Vaccine Development (CVD) and Texas Children’s Hospital Endowed Chair of Tropical Pediatrics.

I think it is premature to make definitive statements about the Omicron variant. According to the NY Times, "The variant was identified on Thursday by scientists in South Africa. So far the variant has been detected in South Africa and Botswana, as well as in a few travelers to Belgium, Britain, Germany, Israel, Italy and Hong Kong."

It may be somewhat more transmissible than Delta, or maybe the same. Symptomatically, it may or may not be worse than Delta, which is pretty bad (there were similar concerns about Gamma, Lambda and Mu, and they fizzled outside there original region). Vaccination should help, but to what extent? The companies provided vaccinations are working to adjust their vaccines for Omicron. Wearing masks in public, or in enclosed spaces frequented by the public, should still be effective.

https://www.nytimes.com/interactive/2021/health/coronavirus-variant-tracker.html
Mutations that may help the Coronavirus spread
MutationLineageStatus
D614GB.1Appeared in early 2020 and spread around the world.
N501YSeveralA defining mutation in several lineages, including B.1.1.7 (Alpha), B.1.351 (Beta) and P.1 (Gamma). Helps the virus bind more tightly to human cells.
E484K or “EekSeveralAppears in several lineages. May help the virus avoid some kinds of antibodies.
K417SeveralAppears in several lineages, including B.1.351 (Beta) and P.1 (Gamma). May help the virus bind more tightly to cells.
L452RSeveralAppears in several lineages, including B.1.617.2 (Delta).

International travelers should be vaccinated, and preferably tested before and after traveling, assuming international travel is not banned.https://www.gisaid.org/hcov19-variants/

Country Submission Count​

CountryTotal #GR/484A (B.1.1.529)#GR/484A (B.1.1.529) in past 4 weeks%GR/484A (B.1.1.529) in past 4 weeks
South Africa999969.7
Botswana191918.6
Australia220.1
Hong Kong228.3
Italy110.0
Israel110.1
Belgium110.0
 
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  • #57
Jarvis323 said:
For me, it's not a thing you just balance out in terms of how much fear, or lack of fear, that people should have. It's a thing you Pareto-optimize in terms of measures you take. You could be someone with almost no concern, and it still makes sense to wear an n95 mask in public. It's about minimizing risk, while also minimizing cost.
My main concern is inhibiting our freedoms that we've (apparently) fought for decades to ensure, then we just throw that away in the face of people saying 'ah, there is a common need for us all to lock ourselves away'.

We need to minimise that to the absolute minimum, there is no justification for exceeding a need to do what is adequate.

On the contrary, we have, as humans, been responsible for our own health since, well, forever, and people aren't generally so stupid that they ignore all risks. If you are concerned for a given infection risk, you avoid the situations likely to give you that.

This is why it's made no difference in countries like Sweden where there has been no enforcement ... because people wear masks and avoid situations without having to be told to do so.

I'm just asking what the risk actually is, if we know and if we don't we need to figure that out quickly to minimise the infringement on people's freedom and liberties.

It is right and proper for all thinking people who value freedom to be asking what is actually required, not to willingly accept a total over-kill impacting our liberties when it is not necessary. Therefore, to ask after the severity of this variant is the key question. Which is all I asked.

For as long as we don't know, then it is OK that we can take precautions, but to impose such precautions without also seeking an answer to that question as soon as possible is, in my view, very hypocritical and an infringement of liberties.
 
  • #58
Astronuc said:
So far the variant has been detected in South Africa and Botswana, as well as in a few travelers to Belgium, Britain, Germany, Israel, Italy and Hong Kong."

Omicron Netherlands: 13 air passengers test positive for new variant
https://www.bbc.com/news/world-europe-59451103

That's 13 of 61 persons who tested positive for SARS-Cov-2 on two planes arriving at Schipol Airport in the Netherlands. Ostensibly, the others have Delta?

The BBC article mentions: "Cases of the new variant have also been confirmed in several European countries, including the UK, Germany and Italy, as well as Botswana, Israel, Australia and Hong Kong." Sure enough, apparently Australia has identified two cases of Omicron variant!

The Netherlands and Australia find the omicron variant as curbs spread​

https://www.npr.org/2021/11/28/1059...alia-find-the-omicron-variant-as-curbs-spread

https://www.nytimes.com/live/2021/11/28/world/covid-omicron-variant-news
In Australia, officials said that Omicron was detected in two travelers who flew into Sydney on Saturday evening on a Qatar Airways flight from Doha. They were asymptomatic and fully vaccinated, according to a statement from the health authority in New South Wales State. The travelers were placed into quarantine.

In the same article, one image shows international departure flights from Johannesburg. One flight, QR1364, to Doha is canceled on November 27.

In the same NYTimes article,
In Denmark, officials said that Omicron was detected in two travelers who had recently arrived from South Africa. Both are in isolation, and their close contacts are being traced, according to a statement by the State Serum Institute, Denmark’s infectious disease authority.


Dr Angelique Coetzee, the South African doctor who first spotted the new Covid variant Omicron, says the patients seen so far have had "extremely mild symptoms" - but more time is needed before we know the seriousness of the disease for vulnerable people.
However, the doctor is waiting to see how significant the Omnicron variant might be for the more vulnerable population.
 
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  • #59
Astronuc said:
Heart disease, cancer, diabetes, and other chronic conditions are not transmissible to others. In addition to the mortality and potentially detrimental effects to the one's health, SARS-Cov-2 is readily transmissible to others.

As with other transmissible diseases, like measles, mumps, rubella, . . . . , various governments and health agencies hope to vaccinate as many as possible, in order to reduce the threat to the public health.
This is the point that is often overlooked. We have had only 140,000 deaths from COVID in the UK because we have locked down and generally taken extreme measures to control the disease. Without these controls, the deaths would have been at least 500,000 - and the overload on the hospitals and ICU beds in particular may have meant many more non-COVID related deaths.

We have the hospital infrastructure in the UK to deal with about 600,000 deaths annually, but we do not have the infrastructure to cope with 1 million deaths in a given year. That's what we were facing before the vaccination roll-out.

The idea that lockdowns and other measures made no difference is ludicrous and irrational.
 
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  • #60
cmb said:
It is right and proper for all thinking people who value freedom to be asking what is actually required, not to willingly accept a total over-kill impacting our liberties when it is not necessary
Its nice to see someone with an open mind.
No one knows what is actually required (except apparently the idiots among us). We do know things that help.

.
 
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  • #61
PeroK said:
This is the point that is often overlooked.
I've been pondering the decimation of indigenous peoples in the Americas to diseases such as measles, mumps, influenza and small pox, introduced by Europeans.

From a national security (public health) perspective, consider the SARS-Cov-2 virus as a biological 'weapon of mass destruction', then act accordingly. Most governments have the responsibility of preventing the spread of such a weapon and protecting the population.
 
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  • #62
hutchphd said:
Its nice to see someone with an open mind.
No one knows what is actually required (except apparently the idiots among us). We do know things that help.
Help what, exactly? I thought we don't yet know the severity of this variant?

Have there been any hospitalisations from this new variant? Deaths?

The way the statistics stand at the moment in the UK is the contradictory conclusion that you will live longer if you have Covid.

Average life expectancy in the UK; 81 years old

Average age of death from Covid; 83 years old.

What does this mean? That you live 2 years longer if you catch Covid?

https://www.ons.gov.uk/peoplepopula...ns/nationallifetablesunitedkingdom/2018to2020

https://www.ons.gov.uk/aboutus/tran...ionfoi/averageageofthosewhohaddiedwithcovid19
 
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  • #64
cmb said:
Help what, exactly? I thought we don't yet know the severity of this variant?

Have there been any hospitalisations from this new variant? Deaths?

The way the statistics stand at the moment in the UK is the contradictory conclusion that you will live longer if you have Covid.

Average life expectancy in the UK; 81 years old

Average age of death from Covid; 83 years old.

What does this mean? That you live 2 years longer if you catch Covid?

https://www.ons.gov.uk/peoplepopula...ns/nationallifetablesunitedkingdom/2018to2020

https://www.ons.gov.uk/aboutus/tran...ionfoi/averageageofthosewhohaddiedwithcovid19
A good statistician wouldn't make those conclusions based on that data.

But anyways, if you read the data you linked again, you'll see that the latter says mean is 80.3. Mean is average not median.
 
  • #65
Jarvis323 said:
A good statistician wouldn't make those conclusions based on that data.

But anyways, if you read the data you linked again, you'll see that the latter says mean is 80.3. Mean is average not median.
OK, maybe, but if the data for some disease was 'average death 51 versus life expectancy 81', it's pretty normal to assume that means around 30 years of life lost per death. In Covid's case in the UK, it is a negative value, but let's say zero, for the sake of argument. A disease which doesn't alter average life expectancy is hardly something that would ordinarily get a mention.

I'm not trying to make a point, other than what the data appears to be saying.
 
  • #66
cmb said:
In Covid's case in the UK, it is a negative value, but let's say zero, for the sake of argument.
Based on your data it's still a positive value. Life expectancy is 81 and average age of death for person who has had Covid is 80.3.
 
  • #67
cmb said:
What we do know is what the doctor that spotted this has said about it;-
Dr. Coetzee first discovered the variant in a man in his early 30s who displayed symptoms of tiredness and a mild headache. She indicated that those testing positive so far tend to be younger, e.g., university students and younger adults. She also indicated she was waiting to see how severe the response would be for older, and more vulnerable members of the population.

Her experience so far has been that the variant is affecting people who are 40 or younger. Almost half of the patients with Omicron symptoms that she treated were not vaccinated.
https://www.reuters.com/world/afric...n-variant-have-very-mild-symptoms-2021-11-28/
Coetzee said a patient on Nov. 18 reported at her clinic being "extremely fatigued" for two days with body aches and headache.

"Symptoms at that stage was very much related to normal viral infection. And because we haven't seen COVID-19 for the past eight to 10 weeks, we decided to test," she said, adding that the patient and his family turned out to be positive.

I have not seen any comment on the vaccination status of the 30-something year-old patient, but only that "almost half of the patients with Omicron symptoms that she treated were not vaccinated."
 
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  • #68
cmb said:
I'm not trying to make a point, other than what the data appears to be saying.

Your interpretation of the data is wrong. You can find the reason for this in your own link:
Statistician’s comment
"Life expectancy has increased in the UK over the last 40 years, albeit at a slower pace in the last decade.

“However, the Coronavirus pandemic led to a greater number of deaths than normal in 2020. Consequently, in the latest estimates, we see virtually no improvement in life expectancy for females compared to 2015 to 2017 at 82.9 years, while for males life expectancy has fallen back to levels reported for 2012 to 2014, at 79 years. This is the first time we have seen a decline when comparing non-overlapping time periods since the series began in the early 1980s.

“These estimates rely on the assumption that current levels of mortality, which are unusually high, will continue for the rest of someone’s life. Once the Coronavirus pandemic has ended and its consequences for future mortality are known, it is possible that life expectancy will return to an improving trend in the future.”

Pamela Cobb, Centre for Ageing and Demography, Office for National Statistics
Source:
https://www.ons.gov.uk/peoplepopula...ns/nationallifetablesunitedkingdom/2018to2020
 
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  • #69
cmb said:
And if the health risk was really the bottom line 'fix it at all costs' point of action, let us note that heart disease has outpaced Coronavirus through the pandemic. 18 million a year global deaths, typically, compared with 3.7 million for Covid, global deaths Nov-Nov for the last year.

It hasn't outpaced Covid everywhere.

In England, Covid-19 was the leading underlying cause of death among men in 2020, replacing heart disease, and the second largest cause of death among women, after dementia and Alzheimer’s disease. Dementia was also reported as the main pre-existing condition on 25.6% of deaths certificates involving covid-19, the report added.

And in terms of life expectancy,
The Covid-19 pandemic led to the biggest year-on-year drop in life expectancy in England since statistics were first collected in 1981, Public Health England has said.

In 2020, the agency said that “the very high level” of excess deaths because of the pandemic caused life expectancy in England to fall 1.3 years for men to 78.7 and 0.9 years for women to 82.7. This was the lowest life expectancy in England for both sexes since 2011.

https://www.bmj.com/content/374/bmj.n2291

But what we do know is that Covid is causing many young people to suffer serious injury (e.g. organ damage, and brain damage). We may see more effects manifest over long periods of time if those people's life spans are reduced.

Younger adults admitted to hospital with Covid are almost as likely to suffer from complications as those over 50 years old, a study has found.
Four in 10 of those between 19 and 49 developed problems with their kidneys, lungs or other organs while treated.
https://www.google.com/amp/s/www.bbc.com/news/health-57840825.amp
 
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  • #70
The two travellers that tested positive for Covid-19, on a flight from Doha to NSW, Australia, have this variant.
 
  • #71
cmb said:
I'm not trying to make a point, other than what the data appears to be saying.
It sounds like you're saying that everyone who died of COVID would have died anyway, only when they were younger. Look at it this way: if someone went around murdering all the people of age 90+, that would not increase life expectancy! Despite your interpretating the data that way.
 
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  • #72
Please don't paint me out to be some sort of Covid denialist just because I dared to ask how dangerous Omicron actually is.

All diseases are dangerous (as well as murderers [not sure why that is a recurring theme here?] and heart disease). I am just asking about Omicron in perspective. Is it any more harmful than other diseases which are not reportable? I accept that we don't know yet. My point, only point, is that we should want to know this, and the reason I think we should want to know this is so that we do not lose our perspective on risks in life. That is all.
 
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  • #73
Sagittarius A-Star said:
Source:
https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-strategy-address-omicron-b11529-sars-cov-2/

Related Moderna tests:

Source:
https://clinicaltrials.gov/ct2/show/study/NCT04927065

AstraZeneca tests the Covid-19-vaccine AZD2816 based on the gene of the Beta variant:
https://clinicaltrials.gov/ct2/show/NCT04973449

BionTech tests the Covid-19-vaccine BNT162b2SA based on the gene of the Beta variant:
https://clinicaltrials.gov/ct2/show/NCT04368728

BionTech tests the Covid-19-multivariant vaccine BNT162b2 (B.1.1.7 + B.1.617.2) based on the genes of the Alpha and Delta variants:
https://clinicaltrials.gov/ct2/show/NCT05004181
So, if they are working on "better boosters" would it be wise for someone already vaccinated to wait for these to be distributed? Or smarter to get the available booster now?
 
  • #74
gmax137 said:
So, if they are working on "better boosters" would it be wise for someone already vaccinated to wait for these to be distributed? Or smarter to get the available booster now?
A shot in the arm is worth two in the lab!
 
  • #75
cmb said:
Please don't paint me out to be some sort of Covid denialist just because I dared to ask how dangerous Omicron actually is.

All diseases are dangerous (as well as murderers [not sure why that is a recurring theme here?] and heart disease). I am just asking about Omicron in perspective. Is it any more harmful than other diseases which are not reportable? I accept that we don't know yet. My point, only point, is that we should want to know this, and the reason I think we should want to know this is so that we do not lose our perspective on risks in life. That is all.
I suspect that's what the rest of us think is precisely what we are doing. The one thing we cannot do is underestimate the virus and then take that decision back. Constraints may easily be lifted when it's safe to do so; widespread infections cannot be revoked.

We must have learned by now that the key is to act quickly and not wait until the virus is widespread. That decision making process requires people generally to understand that not every measure will turn out to be necessary. It's an inability to grasp that point and the belief in those who cannot grasp it that they are smarter than the rest of us that makes things so difficult. Although, one could argue that modern-day political thinking requires that inability of thought. I.e. we must pretend that everything is predictable and that we should never have to take a precaution that later turns out to have been unnecessary.
 
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  • #76
gmax137 said:
So, if they are working on "better boosters" would it be wise for someone already vaccinated to wait for these to be distributed? Or smarter to get the available booster now?
I cannot give medical advice. You may ask your doctor. The currently dominating variant is Delta, and the current boosters work very good against Delta. Also, I don't know, when/if new vaccine versions will be approved and available in high quantity. Maybe mid of next year?

See also:
Pfizer and BioNTech said they expect more data from lab tests in two weeks at the latest.
“These data will provide more information about whether B.1.1.529 could be an escape variant that may require an adjustment of our vaccine if the variant spreads globally,” the companies said.
Source:
https://www.cnbc.com/2021/11/26/pfi...id-variant-jj-testing-vaccine-against-it.html
 
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  • #77
Mi
PeroK said:
I suspect that's what the rest of us think is precisely what we are doing. The one thing we cannot do is underestimate the virus and then take that decision back. Constraints may easily be lifted when it's safe to do so; widespread infections cannot be revoked.

We must have learned by now that the key is to act quickly and not wait until the virus is widespread. That decision making process requires people generally to understand that not every measure will turn out to be necessary. It's an inability to grasp that point and the belief in those who cannot grasp it that they are smarter than the rest of us that makes things so difficult. Although, one could argue that modern-day political thinking requires that inability of thought. I.e. we must pretend that everything is predictable and that we should never have to take a precaution that later turns out to have been unnecessary.
From my perspective, it's the timing of this thing that is most problematic. I live in Hawaii, and things have been more locked down than anywhere else in the US, which has kept cases fairly low at significant cost.

Anyhow, it was recently decided that all remaining restrictions on gatherings ands organized events (like sports) will be dropped December 1st. Everyone here is psychology and emotionally done with covid. It is going to be almost impossible to have any kind of organized reaction or shutdown due to this variant. I think folks will really lose it.
 
  • #78
Astronuc said:
Prof Peter Hotez MD PhD, who has been on the front lines fighting Covid-19 infections in Houston, has credibility. Hotez is Professor: Departments of Pediatrics and Molecular Virology & Microbiology Baylor College of Medicine Houston, Texas, and Dean of the National School of Tropical Medicine and Professor of Pediatrics and Molecular Virology & Microbiology at Baylor College of Medicine where he is also the Co-director of the Texas Children’s Center for Vaccine Development (CVD) and Texas Children’s Hospital Endowed Chair of Tropical Pediatrics.

I think it is premature to make definitive statements about the Omicron variant. According to the NY Times, "The variant was identified on Thursday by scientists in South Africa. So far the variant has been detected in South Africa and Botswana, as well as in a few travelers to Belgium, Britain, Germany, Israel, Italy and Hong Kong."

It may be somewhat more transmissible than Delta, or maybe the same. Symptomatically, it may or may not be worse than Delta, which is pretty bad (there were similar concerns about Gamma, Lambda and Mu, and they fizzled outside there original region). Vaccination should help, but to what extent? The companies provided vaccinations are working to adjust their vaccines for Omicron. Wearing masks in public, or in enclosed spaces frequented by the public, should still be effective.

https://www.nytimes.com/interactive/2021/health/coronavirus-variant-tracker.html
MutationLineageStatus
Mutations that may help the Coronavirus spread
D614GB.1Appeared in early 2020 and spread around the world.
N501YSeveralA defining mutation in several lineages, including B.1.1.7 (Alpha), B.1.351 (Beta) and P.1 (Gamma). Helps the virus bind more tightly to human cells.
E484K or “EekSeveralAppears in several lineages. May help the virus avoid some kinds of antibodies.
K417SeveralAppears in several lineages, including B.1.351 (Beta) and P.1 (Gamma). May help the virus bind more tightly to cells.
L452RSeveralAppears in several lineages, including B.1.617.2 (Delta).

International travelers should be vaccinated, and preferably tested before and after traveling, assuming international travel is not banned.https://www.gisaid.org/hcov19-variants/

Country Submission Count​

CountryTotal #GR/484A (B.1.1.529)#GR/484A (B.1.1.529) in past 4 weeks%GR/484A (B.1.1.529) in past 4 weeks
South Africa999969.7
Botswana191918.6
Australia220.1
Hong Kong228.3
Italy110.0
Israel110.1
Belgium110.0
I was apologizing for using Twitter as a source. That would normally make me feel a little dirty. But web searching right now results in a bazillion news articles, so I had to fall back to a few folks I find to be reliable with real Covid science.
 
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  • #79
valenumr said:
Mi

From my perspective, it's the timing of this thing that is most problematic. I live in Hawaii, and things have been more locked down than anywhere else in the US, which has kept cases fairly low at significant cost.

Anyhow, it was recently decided that all remaining restrictions on gatherings ands organized events (like sports) will be dropped December 1st. Everyone here is psychology and emotionally done with covid. It is going to be almost impossible to have any kind of organized reaction or shutdown due to this variant. I think folks will really lose it.
I understand all that. But, perhaps, COVID isn't done with us yet!
 
  • #80
PeroK said:
I understand all that. But, perhaps, COVID isn't done with us yet!
I know. People here are still good about masking up indoors and we have a vax pass concept. But I think the general sentiment is such that there can only be a reaction to omicron, as opposed to a pre-action. In other words, once again, nothing will happen until it's too late.
 
  • #81
valenumr said:
I know. People here are still good about masking up indoors and we have a vax pass concept. But I think the general sentiment is such that there can only be a reaction to omicron, as opposed to a pre-action. In other words, once again, nothing will happen until it's too late.
One of my favourite quotations is from Kafka's The Trial. It perhaps sums up where we are with COVID. It's better in German, but here's a rough translation:

The script is unalterable, and the opinions about it are often nothing more than an expression of despair.

In fact, there are so many quotations from that book that resonate with the world today. For example:

The lie will become the new world order.

One doesn't have to accept everything as true, only to accept that it is necessary.
 
  • #82
Nobody I've actually spoken to in-person particularly knows nor cares about this new variant. The UK, at least, is almost entirely vaccinated. It seems absurd to entertain the prospect a fresh lockdown, given that market-behaviour was only just returning to pre-pandemic normalcy and healthy growth targets were beginning to be forecast. Unfortunately the market reacts to speculation over policy, rather than the virus itself...
 
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  • #83
valenumr said:
In other words, once again, nothing will happen until it's too late.
I Germany nothing happened and it is already too late. Yesterday, 50 ICU patients from East- and South-Germany where brought with special army planes and helicopters to North-Germany, because of full ICUs.

Source:
https://www.zeit.de/gesundheit/2021-11/luftwaffe-muenchen-hamburg-covid-19-patienten

The infection incidence is rising exponentially.

Source:
https://www.tagesschau.de/inland/coronavirus-karte-deutschland-101.html
 
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  • #85
Sagittarius A-Star said:
I Germany nothing happened and it is already too late. Yesterday, 50 ICU patients from East- and South-Germany where brought with special army planes and helicopters to North-Germany, because of full ICUs.

Source:
https://www.zeit.de/gesundheit/2021-11/luftwaffe-muenchen-hamburg-covid-19-patienten

The infection incidence is rising exponentially.

Source:
https://www.tagesschau.de/inland/coronavirus-karte-deutschland-101.html
Yikes. We had that happen with Delta. It was going around everywhere, and we just kept opening up. Then we had a massive spike in cases. Granted the guidelines were based on vaccination rates, but those were based on science of Covid classic.
 
  • #86
A lot of people here, and probably in all countries, were against the use of mask, or against the lockdown. Fortunatelly, it was the minory. I am afraid that if this new variant in fact start to spread just like covid, more people will got more impatient and will not follow the rules.
 
  • #87
PeroK said:
We must have learned by now that the key is to act quickly and not wait until the virus is widespread.
This is predicated on the axiom that there are steps that can be taken to avoid it becoming widespread.

Evidence suggests there is no chance of this.

There have been several countries that have tried total lockdown, one in particular at the far end of every travel route, being New Zealand, that had the most optimum of a good long prewarning. What is happening there now? Despite their heroic efforts to stop it becoming widespread there, and despite the enormous sacrifice of its people to their freedoms, I fear that battle is now lost.

The original prospectus for lockdowns was to avoid the peak of cases, so that hospitals had a chance to deal with the waves. Although there were some rushes on hospitals, nothing like what was planned for. UK 'Nightingale' hospitals went completely unused. Then the lockdown morphed into giving us enough time for vaccinations, which are now widespread. Now we have a lockdown to do, what? To stop it becoming a widespread endemic?

That battle is lost on whether it (and its variants) will become widespread. The question is whether its variants will run out of virility to do much harm, more than any other endemic disease, as they mutate.

What are we actually doing and why? We might well reduce the rate of cases and mortality, flattening the peaks, but are the magnitude of cases and mortality actually going to be affected in the long run?

New Zealand is a good test case. Its cases are now on the rise. Will it end up low on the deaths-per-million, and gain credit for all that hard work, or just merge into the spectrum of outcomes across the world by the end of next year?

I am lost in the current thinking, I don't understand any of the objectives any more. Saying 'it's to save lives' sounds like a political statement not a scientific one, because you just have to scan the list of countries according to rates of death/M and on the face of it it looks random and uncorrelated to how well or badly or quickly lockdowns were implemented. Some counties that were held up as ideal examples are now bad on the list of deaths/M. Others that looked like a sham are orders of magnitude better.

For example, people laughed at Madagascar when the Gov released a local tea, saying this would stop Covid. They did have a lockdown .. for a couple of weeks, in a couple of larger towns. Well, at 34 deaths per million population, while USA is at 2,400 per million, who is laughing about that now?

Then there was India that initially looked fine and everyone said how well they had done, then it surged and folks said how badly they'd dealt with the second wave, now at 330/M deaths, they're looking pretty good by comparison with USA and, say, UK at 2,100/M.

Iran was slated badly by the international community for not locking down for a long time, and eventually they got all panicky about it. Currently they are at 1,500/M, so hardly doing 'badly' against say Germany that was also held up as an icon of lockdown implementation, now much the same at 1,200/M.

Peru locked down with military force and closed the borders very quickly, now at 6,000/M.

I'm not seeing strong correlations between the massive (or small) impositions on society and 'results'.

We can scientifically rationalise and intellectualise what we should or should not do, but how is it actually translating into real results, or not? Australia has come down very hard on its population and ended up with just 77/M deaths. Is that from vigorously applied lockdowns, or have then been sneaking in some Malagasy tea?

I'm sorry but I am just struggling to see correlations here. As humans we should take responsibility for ourselves, I have taken the vaccinations and I keep away from people, like we all should. But then I always have and being on the autistic spectrum my OCD habits which were once ridiculed have now become normalised.

I think it is unfair to accuse people of not taking the pandemic seriously and becoming 'spreaders' of it. If you worry about it that much, stay at home. If you worry a bit about it and have some perspective, take the vaccines and avoid potentially bad situations. If you couldn't care less about your health, then please sign a thing that says you'd prefer not to be treated in hospital, so I don't find you there if I need it.

It seems to me that the world has lost its perspective. How come the death rate varies by two orders of magnitude across the globe, with the countries practicing the most stringent lock downs appearing at both ends and also in the middle? Likewise the countries with the least stringent lockdowns also appear at both ends of that 2-OOM spectrum? I'm just not seeing a correlation between mortality outcomes and how countries have responded. Sorry. The death rate numbers objectively disclose this.
 
  • #88
PeroK said:
Definitely! But the sad reality is that it's been like this from the start, and was always expected to get worse during the Winter. But is it sustainable to lock down the entire country every time a new variant - of which this will be far from the last - arises?

I think Sir John Bell put it nicely, emphasising the protection provided by existing immunity.
You could still have a highly infectious virus that scoots around and causes lots of trouble, but causes lots of, you know, runny noses and headaches but doesn't put people into hospital. Honestly, you could live with that, I think. https://www.telegraph.co.uk/news/20...t-less-worrying-delta-says-prof-chris-whitty/
 
  • #89
What's really messed up is that this is the third novel Corona outbreak in a total of 17 years. It's starting to seem probable that we get a new one before this is even over.
 
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  • #90
cmb said:
What does this mean? That you live 2 years longer if you catch Covid?
No it certainly does not, and you should be able to figure that out.
cmb said:
I think it is unfair to accuse people of not taking the pandemic seriously and becoming 'spreaders' of it. If you worry about it that much, stay at home. If you worry a bit about it and have some perspective, take the vaccines and avoid potentially bad situations. If you couldn't care less about your health, then please sign a thing that says you'd prefer not to be treated in hospital, so I don't find you there if I need it.
But of course no one will eschew the ER when they cannot breathe. And no ER will turn them away. So if I have an infarction, I will die from their unvaccinated stupidity because the ER is full.
We do not have and will never have all the answers. People do not and will not behave as rational actors. To predicate our actions on these assumptions is foolish and to proselytize on this basis is reckless. So we do the best we can here in the real world.
 
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  • #91
hutchphd said:
We do not have and will never have all the answers. People do not and will not behave as rational actors. To predicate our actions on these assumptions is foolish and to proselytize on this basis is reckless. So we do the best we can here in the real world.
COVID is the last straw for my belief that universal healthcare, free at the point of use, is sustainable. Nominally, that is what we have in the UK but in a practical sense we simply no longer have healthcare except for emergencies. I'm already dependent on my private health insurance to get a telephone appointment with a "family doctor" - GP as they are callled here. There is no prospect of my seeing an NHS GP face-to-face or even on the telephone.

I have arthritis and it would take forever to see a GP, then a specialist, then have a scan, then see the specialist again and finally get treatment. This would nominally be free on the NHS, but in practical terms this sort of non-emergency treatment is no longer readily available (*). No one wants to face the political realities of a healthcare system that can barely cope in any case and now has to content with unvaccinated COVID patients - all demanding their unlimited free healthcare.

It seems that we have too many scared cows now and sooner or later we have to choose one to be slaughtered.

(*) Last year I went through that cycle privately in 2-3 weeks.
 
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  • #92
With Omicron the real alarm is the number of mutations that have arisen in a relatively short period of time.

Here's the genetic sequence with mutations for Omicron - https://en.wikipedia.org/wiki/SARS-CoV-2_Omicron_variant -

"The variant has a large number of mutations, of which some are concerning.[11] Thirty-two mutations affect the spike protein, the main antigenic target of antibodies generated by infections and of many vaccines widely administered. Many of those mutations had not been observed in other strains.[12][13] The variant is characterised by 30 amino acid changes, three small deletions and one small insertion in the spike protein compared with the original virus, of which 15 are located in the receptor binding domain (residues 319-541). It also carries a number of changes and deletions in other genomic regions. Of note, the variant has three mutations at the furin cleavage site.[14] The furin cleavage site increases SARS-CoV-2 infectivity.[15] The mutations by genomic region are the following:[16][10]

  • Spike protein: A67V, Δ69-70, T95I, G142D, Δ143-145, Δ211, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F
    • Half (15) of these 30 changes are located in the receptor binding domain-RBD (residues 319-541)
  • ORF1ab
    • nsp3: K38R, V1069I, Δ1265, L1266I, A1892T
    • nsp4: T492I
    • nsp5: P132H
    • nsp6: Δ105-107, A189V
    • nsp12: P323L
    • nsp14: I42V
  • Envelope protein: T9I
  • Membrane protein: D3G, Q19E, A63T
  • Nucleocapsid protein: P13L, Δ31-33, R203K, G204R"
vs the genetic sequence with mutations for Delta - https://en.wikipedia.org/wiki/SARS-CoV-2_Delta_variant

What is it about the spike protein sequences (genetic structure) that generates increasing mutations rates?
 
  • #93
At least everyone is learning the Greek alphabet, but not heard of the xi variant. Probably too much like '6' and skipped?
 
  • #94
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  • #95
valenumr said:
Yikes. We had that happen with Delta. It was going around everywhere, and we just kept opening up. Then we had a massive spike in cases. Granted the guidelines were based on vaccination rates, but those were based on science of Covid classic.
Where?
 
  • #96
gmax137 said:
So, if they are working on "better boosters" would it be wise for someone already vaccinated to wait for these to be distributed? Or smarter to get the available booster now?
My view of boosters is that if you're in a vulnerable category, then getting one now is warranted and worth it. Otherwise, it's maybe not the biggest problem in the world to not get one if you're healthy and relatively young.

Boosters mainly offer an additional layer of protection (upping your active neutralizing antibodies, which decay over time - often heavily depleted or even gone after a few months) vs. those who are fully vaccinated w/o the booster yet. Those antibodies will give you a small advantage in preventing infection, but probably not much of one in regards to severe health complications.

The "original full vaccinations" already give you long-term protection in the form of memory T and memory B cells, which help your body fight the infection if you get COVID. Whereas antibodies decay over time, memory T & B cells increase over time, from cell division. This will mean years of protection from severe illness, even if infection protection wanes over time w/o boosters.

eta: ...assuming Omicron doesn't break through memory T & B cell illness protection, of course.

The question I have is:
If a booster for omicron comes out (or some other new and improved one), how quickly can a person who has already had a booster get the latest/best one? E.g.,

If I got a Moderna booster today and tomorrow it was announced that an omicron booster is available, could I get it immediately?
 
  • #97
kyphysics said:
If I got a Moderna booster today and tomorrow it was announced that an omicron booster is available, could I get it immediately?

The Omicron booster will not be be available tomorrow.
The Berlin virologist Christian Drosten is worried about the new Omikron variant of the corona virus. “I'm pretty worried at the moment,” said Drosten on Sunday evening in the ZDF “heute journal”.

You don't know too much about the new variant. Reports of mild courses did not yet have a lot of substance in view of only a good 1000 cases. Here you have to wait for the clinical course.

You can see, however, that it occurs frequently among young people in South Africa and also affects people who have already had an illness. He is concerned that the first real "immune escape mutant" is in front of him.

It is also not yet possible to say how the variant behaves in this country, where many people have been vaccinated.

“Nobody can say at the moment what is in store for us. The only thing you can really say for sure is: it's better to be vaccinated. It's even better when you're boosted, ”said Drosten. The available vaccines would probably protect against a serious course of the disease.
Source
https://www.bz-berlin.de/berlin/dro...mutation-bin-schon-ziemlich-besorgt-im-moment

via Google translate:
https://translate.google.com/?hl=de...Krankheitsverlauf wohl schützen.&op=translate
 
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  • #98
Yes, it was a hypothetical question.

I did see Fauci, however, answer the "wait for a tweaked booster" question by saying not to wait. We cannot know for sure if/when a better/tweaked booster will come out, so he recommends not playing these games and just getting boosted now. Sounds like solid advice.
 
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  • #99
atyy said:
Where?
Hawaii.
 
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