COVID Covid Variant Omicron (B.1.1.529)

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A new Covid-19 variant, B.1.1.529, has emerged in Botswana and South Africa, raising concerns due to its high number of mutations, particularly on the spike protein, which could affect vaccine efficacy. Scientists warn that this variant may evade monoclonal antibodies, potentially leading to new outbreaks as countries reopen borders. The UK has responded by banning flights from several African nations and reintroducing quarantine measures for travelers. The World Health Organization is set to evaluate the variant, which may be classified as a variant of concern, and could be named Omicron. The situation remains fluid as researchers continue to monitor the variant's spread and impact on public health.
  • #61
PeroK said:
This is the point that is often overlooked.
I've been pondering the decimation of indigenous peoples in the Americas to diseases such as measles, mumps, influenza and small pox, introduced by Europeans.

From a national security (public health) perspective, consider the SARS-Cov-2 virus as a biological 'weapon of mass destruction', then act accordingly. Most governments have the responsibility of preventing the spread of such a weapon and protecting the population.
 
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  • #62
hutchphd said:
Its nice to see someone with an open mind.
No one knows what is actually required (except apparently the idiots among us). We do know things that help.
Help what, exactly? I thought we don't yet know the severity of this variant?

Have there been any hospitalisations from this new variant? Deaths?

The way the statistics stand at the moment in the UK is the contradictory conclusion that you will live longer if you have Covid.

Average life expectancy in the UK; 81 years old

Average age of death from Covid; 83 years old.

What does this mean? That you live 2 years longer if you catch Covid?

https://www.ons.gov.uk/peoplepopula...ns/nationallifetablesunitedkingdom/2018to2020

https://www.ons.gov.uk/aboutus/tran...ionfoi/averageageofthosewhohaddiedwithcovid19
 
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  • #64
cmb said:
Help what, exactly? I thought we don't yet know the severity of this variant?

Have there been any hospitalisations from this new variant? Deaths?

The way the statistics stand at the moment in the UK is the contradictory conclusion that you will live longer if you have Covid.

Average life expectancy in the UK; 81 years old

Average age of death from Covid; 83 years old.

What does this mean? That you live 2 years longer if you catch Covid?

https://www.ons.gov.uk/peoplepopula...ns/nationallifetablesunitedkingdom/2018to2020

https://www.ons.gov.uk/aboutus/tran...ionfoi/averageageofthosewhohaddiedwithcovid19
A good statistician wouldn't make those conclusions based on that data.

But anyways, if you read the data you linked again, you'll see that the latter says mean is 80.3. Mean is average not median.
 
  • #65
Jarvis323 said:
A good statistician wouldn't make those conclusions based on that data.

But anyways, if you read the data you linked again, you'll see that the latter says mean is 80.3. Mean is average not median.
OK, maybe, but if the data for some disease was 'average death 51 versus life expectancy 81', it's pretty normal to assume that means around 30 years of life lost per death. In Covid's case in the UK, it is a negative value, but let's say zero, for the sake of argument. A disease which doesn't alter average life expectancy is hardly something that would ordinarily get a mention.

I'm not trying to make a point, other than what the data appears to be saying.
 
  • #66
cmb said:
In Covid's case in the UK, it is a negative value, but let's say zero, for the sake of argument.
Based on your data it's still a positive value. Life expectancy is 81 and average age of death for person who has had Covid is 80.3.
 
  • #67
cmb said:
What we do know is what the doctor that spotted this has said about it;-
Dr. Coetzee first discovered the variant in a man in his early 30s who displayed symptoms of tiredness and a mild headache. She indicated that those testing positive so far tend to be younger, e.g., university students and younger adults. She also indicated she was waiting to see how severe the response would be for older, and more vulnerable members of the population.

Her experience so far has been that the variant is affecting people who are 40 or younger. Almost half of the patients with Omicron symptoms that she treated were not vaccinated.
https://www.reuters.com/world/afric...n-variant-have-very-mild-symptoms-2021-11-28/
Coetzee said a patient on Nov. 18 reported at her clinic being "extremely fatigued" for two days with body aches and headache.

"Symptoms at that stage was very much related to normal viral infection. And because we haven't seen COVID-19 for the past eight to 10 weeks, we decided to test," she said, adding that the patient and his family turned out to be positive.

I have not seen any comment on the vaccination status of the 30-something year-old patient, but only that "almost half of the patients with Omicron symptoms that she treated were not vaccinated."
 
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  • #68
cmb said:
I'm not trying to make a point, other than what the data appears to be saying.

Your interpretation of the data is wrong. You can find the reason for this in your own link:
Statistician’s comment
"Life expectancy has increased in the UK over the last 40 years, albeit at a slower pace in the last decade.

“However, the Coronavirus pandemic led to a greater number of deaths than normal in 2020. Consequently, in the latest estimates, we see virtually no improvement in life expectancy for females compared to 2015 to 2017 at 82.9 years, while for males life expectancy has fallen back to levels reported for 2012 to 2014, at 79 years. This is the first time we have seen a decline when comparing non-overlapping time periods since the series began in the early 1980s.

“These estimates rely on the assumption that current levels of mortality, which are unusually high, will continue for the rest of someone’s life. Once the Coronavirus pandemic has ended and its consequences for future mortality are known, it is possible that life expectancy will return to an improving trend in the future.”

Pamela Cobb, Centre for Ageing and Demography, Office for National Statistics
Source:
https://www.ons.gov.uk/peoplepopula...ns/nationallifetablesunitedkingdom/2018to2020
 
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  • #69
cmb said:
And if the health risk was really the bottom line 'fix it at all costs' point of action, let us note that heart disease has outpaced Coronavirus through the pandemic. 18 million a year global deaths, typically, compared with 3.7 million for Covid, global deaths Nov-Nov for the last year.

It hasn't outpaced Covid everywhere.

In England, Covid-19 was the leading underlying cause of death among men in 2020, replacing heart disease, and the second largest cause of death among women, after dementia and Alzheimer’s disease. Dementia was also reported as the main pre-existing condition on 25.6% of deaths certificates involving covid-19, the report added.

And in terms of life expectancy,
The Covid-19 pandemic led to the biggest year-on-year drop in life expectancy in England since statistics were first collected in 1981, Public Health England has said.

In 2020, the agency said that “the very high level” of excess deaths because of the pandemic caused life expectancy in England to fall 1.3 years for men to 78.7 and 0.9 years for women to 82.7. This was the lowest life expectancy in England for both sexes since 2011.

https://www.bmj.com/content/374/bmj.n2291

But what we do know is that Covid is causing many young people to suffer serious injury (e.g. organ damage, and brain damage). We may see more effects manifest over long periods of time if those people's life spans are reduced.

Younger adults admitted to hospital with Covid are almost as likely to suffer from complications as those over 50 years old, a study has found.
Four in 10 of those between 19 and 49 developed problems with their kidneys, lungs or other organs while treated.
https://www.google.com/amp/s/www.bbc.com/news/health-57840825.amp
 
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  • #70
The two travellers that tested positive for Covid-19, on a flight from Doha to NSW, Australia, have this variant.
 
  • #71
cmb said:
I'm not trying to make a point, other than what the data appears to be saying.
It sounds like you're saying that everyone who died of COVID would have died anyway, only when they were younger. Look at it this way: if someone went around murdering all the people of age 90+, that would not increase life expectancy! Despite your interpretating the data that way.
 
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  • #72
Please don't paint me out to be some sort of Covid denialist just because I dared to ask how dangerous Omicron actually is.

All diseases are dangerous (as well as murderers [not sure why that is a recurring theme here?] and heart disease). I am just asking about Omicron in perspective. Is it any more harmful than other diseases which are not reportable? I accept that we don't know yet. My point, only point, is that we should want to know this, and the reason I think we should want to know this is so that we do not lose our perspective on risks in life. That is all.
 
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  • #73
Sagittarius A-Star said:
Source:
https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-strategy-address-omicron-b11529-sars-cov-2/

Related Moderna tests:

Source:
https://clinicaltrials.gov/ct2/show/study/NCT04927065

AstraZeneca tests the Covid-19-vaccine AZD2816 based on the gene of the Beta variant:
https://clinicaltrials.gov/ct2/show/NCT04973449

BionTech tests the Covid-19-vaccine BNT162b2SA based on the gene of the Beta variant:
https://clinicaltrials.gov/ct2/show/NCT04368728

BionTech tests the Covid-19-multivariant vaccine BNT162b2 (B.1.1.7 + B.1.617.2) based on the genes of the Alpha and Delta variants:
https://clinicaltrials.gov/ct2/show/NCT05004181
So, if they are working on "better boosters" would it be wise for someone already vaccinated to wait for these to be distributed? Or smarter to get the available booster now?
 
  • #74
gmax137 said:
So, if they are working on "better boosters" would it be wise for someone already vaccinated to wait for these to be distributed? Or smarter to get the available booster now?
A shot in the arm is worth two in the lab!
 
  • #75
cmb said:
Please don't paint me out to be some sort of Covid denialist just because I dared to ask how dangerous Omicron actually is.

All diseases are dangerous (as well as murderers [not sure why that is a recurring theme here?] and heart disease). I am just asking about Omicron in perspective. Is it any more harmful than other diseases which are not reportable? I accept that we don't know yet. My point, only point, is that we should want to know this, and the reason I think we should want to know this is so that we do not lose our perspective on risks in life. That is all.
I suspect that's what the rest of us think is precisely what we are doing. The one thing we cannot do is underestimate the virus and then take that decision back. Constraints may easily be lifted when it's safe to do so; widespread infections cannot be revoked.

We must have learned by now that the key is to act quickly and not wait until the virus is widespread. That decision making process requires people generally to understand that not every measure will turn out to be necessary. It's an inability to grasp that point and the belief in those who cannot grasp it that they are smarter than the rest of us that makes things so difficult. Although, one could argue that modern-day political thinking requires that inability of thought. I.e. we must pretend that everything is predictable and that we should never have to take a precaution that later turns out to have been unnecessary.
 
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  • #76
gmax137 said:
So, if they are working on "better boosters" would it be wise for someone already vaccinated to wait for these to be distributed? Or smarter to get the available booster now?
I cannot give medical advice. You may ask your doctor. The currently dominating variant is Delta, and the current boosters work very good against Delta. Also, I don't know, when/if new vaccine versions will be approved and available in high quantity. Maybe mid of next year?

See also:
Pfizer and BioNTech said they expect more data from lab tests in two weeks at the latest.
“These data will provide more information about whether B.1.1.529 could be an escape variant that may require an adjustment of our vaccine if the variant spreads globally,” the companies said.
Source:
https://www.cnbc.com/2021/11/26/pfi...id-variant-jj-testing-vaccine-against-it.html
 
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  • #77
Mi
PeroK said:
I suspect that's what the rest of us think is precisely what we are doing. The one thing we cannot do is underestimate the virus and then take that decision back. Constraints may easily be lifted when it's safe to do so; widespread infections cannot be revoked.

We must have learned by now that the key is to act quickly and not wait until the virus is widespread. That decision making process requires people generally to understand that not every measure will turn out to be necessary. It's an inability to grasp that point and the belief in those who cannot grasp it that they are smarter than the rest of us that makes things so difficult. Although, one could argue that modern-day political thinking requires that inability of thought. I.e. we must pretend that everything is predictable and that we should never have to take a precaution that later turns out to have been unnecessary.
From my perspective, it's the timing of this thing that is most problematic. I live in Hawaii, and things have been more locked down than anywhere else in the US, which has kept cases fairly low at significant cost.

Anyhow, it was recently decided that all remaining restrictions on gatherings ands organized events (like sports) will be dropped December 1st. Everyone here is psychology and emotionally done with covid. It is going to be almost impossible to have any kind of organized reaction or shutdown due to this variant. I think folks will really lose it.
 
  • #78
Astronuc said:
Prof Peter Hotez MD PhD, who has been on the front lines fighting Covid-19 infections in Houston, has credibility. Hotez is Professor: Departments of Pediatrics and Molecular Virology & Microbiology Baylor College of Medicine Houston, Texas, and Dean of the National School of Tropical Medicine and Professor of Pediatrics and Molecular Virology & Microbiology at Baylor College of Medicine where he is also the Co-director of the Texas Children’s Center for Vaccine Development (CVD) and Texas Children’s Hospital Endowed Chair of Tropical Pediatrics.

I think it is premature to make definitive statements about the Omicron variant. According to the NY Times, "The variant was identified on Thursday by scientists in South Africa. So far the variant has been detected in South Africa and Botswana, as well as in a few travelers to Belgium, Britain, Germany, Israel, Italy and Hong Kong."

It may be somewhat more transmissible than Delta, or maybe the same. Symptomatically, it may or may not be worse than Delta, which is pretty bad (there were similar concerns about Gamma, Lambda and Mu, and they fizzled outside there original region). Vaccination should help, but to what extent? The companies provided vaccinations are working to adjust their vaccines for Omicron. Wearing masks in public, or in enclosed spaces frequented by the public, should still be effective.

https://www.nytimes.com/interactive/2021/health/coronavirus-variant-tracker.html
MutationLineageStatus
Mutations that may help the Coronavirus spread
D614GB.1Appeared in early 2020 and spread around the world.
N501YSeveralA defining mutation in several lineages, including B.1.1.7 (Alpha), B.1.351 (Beta) and P.1 (Gamma). Helps the virus bind more tightly to human cells.
E484K or “EekSeveralAppears in several lineages. May help the virus avoid some kinds of antibodies.
K417SeveralAppears in several lineages, including B.1.351 (Beta) and P.1 (Gamma). May help the virus bind more tightly to cells.
L452RSeveralAppears in several lineages, including B.1.617.2 (Delta).

International travelers should be vaccinated, and preferably tested before and after traveling, assuming international travel is not banned.https://www.gisaid.org/hcov19-variants/

Country Submission Count​

CountryTotal #GR/484A (B.1.1.529)#GR/484A (B.1.1.529) in past 4 weeks%GR/484A (B.1.1.529) in past 4 weeks
South Africa999969.7
Botswana191918.6
Australia220.1
Hong Kong228.3
Italy110.0
Israel110.1
Belgium110.0
I was apologizing for using Twitter as a source. That would normally make me feel a little dirty. But web searching right now results in a bazillion news articles, so I had to fall back to a few folks I find to be reliable with real Covid science.
 
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  • #79
valenumr said:
Mi

From my perspective, it's the timing of this thing that is most problematic. I live in Hawaii, and things have been more locked down than anywhere else in the US, which has kept cases fairly low at significant cost.

Anyhow, it was recently decided that all remaining restrictions on gatherings ands organized events (like sports) will be dropped December 1st. Everyone here is psychology and emotionally done with covid. It is going to be almost impossible to have any kind of organized reaction or shutdown due to this variant. I think folks will really lose it.
I understand all that. But, perhaps, COVID isn't done with us yet!
 
  • #80
PeroK said:
I understand all that. But, perhaps, COVID isn't done with us yet!
I know. People here are still good about masking up indoors and we have a vax pass concept. But I think the general sentiment is such that there can only be a reaction to omicron, as opposed to a pre-action. In other words, once again, nothing will happen until it's too late.
 
  • #81
valenumr said:
I know. People here are still good about masking up indoors and we have a vax pass concept. But I think the general sentiment is such that there can only be a reaction to omicron, as opposed to a pre-action. In other words, once again, nothing will happen until it's too late.
One of my favourite quotations is from Kafka's The Trial. It perhaps sums up where we are with COVID. It's better in German, but here's a rough translation:

The script is unalterable, and the opinions about it are often nothing more than an expression of despair.

In fact, there are so many quotations from that book that resonate with the world today. For example:

The lie will become the new world order.

One doesn't have to accept everything as true, only to accept that it is necessary.
 
  • #82
Nobody I've actually spoken to in-person particularly knows nor cares about this new variant. The UK, at least, is almost entirely vaccinated. It seems absurd to entertain the prospect a fresh lockdown, given that market-behaviour was only just returning to pre-pandemic normalcy and healthy growth targets were beginning to be forecast. Unfortunately the market reacts to speculation over policy, rather than the virus itself...
 
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  • #83
valenumr said:
In other words, once again, nothing will happen until it's too late.
I Germany nothing happened and it is already too late. Yesterday, 50 ICU patients from East- and South-Germany where brought with special army planes and helicopters to North-Germany, because of full ICUs.

Source:
https://www.zeit.de/gesundheit/2021-11/luftwaffe-muenchen-hamburg-covid-19-patienten

The infection incidence is rising exponentially.

Source:
https://www.tagesschau.de/inland/coronavirus-karte-deutschland-101.html
 
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  • #85
Sagittarius A-Star said:
I Germany nothing happened and it is already too late. Yesterday, 50 ICU patients from East- and South-Germany where brought with special army planes and helicopters to North-Germany, because of full ICUs.

Source:
https://www.zeit.de/gesundheit/2021-11/luftwaffe-muenchen-hamburg-covid-19-patienten

The infection incidence is rising exponentially.

Source:
https://www.tagesschau.de/inland/coronavirus-karte-deutschland-101.html
Yikes. We had that happen with Delta. It was going around everywhere, and we just kept opening up. Then we had a massive spike in cases. Granted the guidelines were based on vaccination rates, but those were based on science of Covid classic.
 
  • #86
A lot of people here, and probably in all countries, were against the use of mask, or against the lockdown. Fortunatelly, it was the minory. I am afraid that if this new variant in fact start to spread just like covid, more people will got more impatient and will not follow the rules.
 
  • #87
PeroK said:
We must have learned by now that the key is to act quickly and not wait until the virus is widespread.
This is predicated on the axiom that there are steps that can be taken to avoid it becoming widespread.

Evidence suggests there is no chance of this.

There have been several countries that have tried total lockdown, one in particular at the far end of every travel route, being New Zealand, that had the most optimum of a good long prewarning. What is happening there now? Despite their heroic efforts to stop it becoming widespread there, and despite the enormous sacrifice of its people to their freedoms, I fear that battle is now lost.

The original prospectus for lockdowns was to avoid the peak of cases, so that hospitals had a chance to deal with the waves. Although there were some rushes on hospitals, nothing like what was planned for. UK 'Nightingale' hospitals went completely unused. Then the lockdown morphed into giving us enough time for vaccinations, which are now widespread. Now we have a lockdown to do, what? To stop it becoming a widespread endemic?

That battle is lost on whether it (and its variants) will become widespread. The question is whether its variants will run out of virility to do much harm, more than any other endemic disease, as they mutate.

What are we actually doing and why? We might well reduce the rate of cases and mortality, flattening the peaks, but are the magnitude of cases and mortality actually going to be affected in the long run?

New Zealand is a good test case. Its cases are now on the rise. Will it end up low on the deaths-per-million, and gain credit for all that hard work, or just merge into the spectrum of outcomes across the world by the end of next year?

I am lost in the current thinking, I don't understand any of the objectives any more. Saying 'it's to save lives' sounds like a political statement not a scientific one, because you just have to scan the list of countries according to rates of death/M and on the face of it it looks random and uncorrelated to how well or badly or quickly lockdowns were implemented. Some counties that were held up as ideal examples are now bad on the list of deaths/M. Others that looked like a sham are orders of magnitude better.

For example, people laughed at Madagascar when the Gov released a local tea, saying this would stop Covid. They did have a lockdown .. for a couple of weeks, in a couple of larger towns. Well, at 34 deaths per million population, while USA is at 2,400 per million, who is laughing about that now?

Then there was India that initially looked fine and everyone said how well they had done, then it surged and folks said how badly they'd dealt with the second wave, now at 330/M deaths, they're looking pretty good by comparison with USA and, say, UK at 2,100/M.

Iran was slated badly by the international community for not locking down for a long time, and eventually they got all panicky about it. Currently they are at 1,500/M, so hardly doing 'badly' against say Germany that was also held up as an icon of lockdown implementation, now much the same at 1,200/M.

Peru locked down with military force and closed the borders very quickly, now at 6,000/M.

I'm not seeing strong correlations between the massive (or small) impositions on society and 'results'.

We can scientifically rationalise and intellectualise what we should or should not do, but how is it actually translating into real results, or not? Australia has come down very hard on its population and ended up with just 77/M deaths. Is that from vigorously applied lockdowns, or have then been sneaking in some Malagasy tea?

I'm sorry but I am just struggling to see correlations here. As humans we should take responsibility for ourselves, I have taken the vaccinations and I keep away from people, like we all should. But then I always have and being on the autistic spectrum my OCD habits which were once ridiculed have now become normalised.

I think it is unfair to accuse people of not taking the pandemic seriously and becoming 'spreaders' of it. If you worry about it that much, stay at home. If you worry a bit about it and have some perspective, take the vaccines and avoid potentially bad situations. If you couldn't care less about your health, then please sign a thing that says you'd prefer not to be treated in hospital, so I don't find you there if I need it.

It seems to me that the world has lost its perspective. How come the death rate varies by two orders of magnitude across the globe, with the countries practicing the most stringent lock downs appearing at both ends and also in the middle? Likewise the countries with the least stringent lockdowns also appear at both ends of that 2-OOM spectrum? I'm just not seeing a correlation between mortality outcomes and how countries have responded. Sorry. The death rate numbers objectively disclose this.
 
  • #88
PeroK said:
Definitely! But the sad reality is that it's been like this from the start, and was always expected to get worse during the Winter. But is it sustainable to lock down the entire country every time a new variant - of which this will be far from the last - arises?

I think Sir John Bell put it nicely, emphasising the protection provided by existing immunity.
You could still have a highly infectious virus that scoots around and causes lots of trouble, but causes lots of, you know, runny noses and headaches but doesn't put people into hospital. Honestly, you could live with that, I think. https://www.telegraph.co.uk/news/20...t-less-worrying-delta-says-prof-chris-whitty/
 
  • #89
What's really messed up is that this is the third novel Corona outbreak in a total of 17 years. It's starting to seem probable that we get a new one before this is even over.
 
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  • #90
cmb said:
What does this mean? That you live 2 years longer if you catch Covid?
No it certainly does not, and you should be able to figure that out.
cmb said:
I think it is unfair to accuse people of not taking the pandemic seriously and becoming 'spreaders' of it. If you worry about it that much, stay at home. If you worry a bit about it and have some perspective, take the vaccines and avoid potentially bad situations. If you couldn't care less about your health, then please sign a thing that says you'd prefer not to be treated in hospital, so I don't find you there if I need it.
But of course no one will eschew the ER when they cannot breathe. And no ER will turn them away. So if I have an infarction, I will die from their unvaccinated stupidity because the ER is full.
We do not have and will never have all the answers. People do not and will not behave as rational actors. To predicate our actions on these assumptions is foolish and to proselytize on this basis is reckless. So we do the best we can here in the real world.
 
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