Newton's Law of Universal Gravitation can be combined with Newton's Second Law of Motion to derive the change in distance between two masses over time. This involves solving coupled differential equations that describe the gravitational interaction between the masses. The discussion highlights that the problem requires calculus, specifically differential equations, to find a solution. The user seeks clarification on a specific equation related to velocity as a function of distance and time, indicating a desire for a simpler explanation. Ultimately, the complexity of the topic necessitates a foundational understanding of calculus for proper analysis.