Designing a powerful and efficient vacuum requires careful consideration of materials and design to achieve sufficient suction to hold a weight against a vertical wall. The force generated by the vacuum depends on the surface area and the level of vacuum achieved, with a 99% vacuum providing adequate force for some applications. Sealing mechanisms are crucial for maintaining suction while allowing movement, with suggestions like using elastomers or pool noodles for edge sealing. Calculations for suction force are similar to those used in hovercraft design, emphasizing the importance of fan specifications and airflow. Overall, achieving a balance between suction, weight, and movement efficiency is key to the success of the vacuum design.