Multiple access refers to techniques that allow multiple users to share the same communication medium, while multiplexing involves combining multiple signals into one signal for transmission over a single channel. Frequency Division Multiple Access (FDMA) uses different frequencies for independent carriers, whereas Time Division Multiple Access (TDMA) encodes time slots on the same carrier, making the terms more interchangeable in this context. The distinction lies in the method of sharing resources: multiple access focuses on user access to a medium, while multiplexing emphasizes signal combination. Understanding these differences is crucial for effective communication system design.