Coulomb's law is fundamentally applicable only to point charges, although it can be used for uniformly charged spheres by applying Newton's shell theorem. For larger or non-uniform charge distributions, Gauss's law is necessary, as it allows for the calculation of electric fields by integrating the effects of differential charge elements. The discussion also touches on the historical context of Coulomb's experiments, suggesting he likely used charged spheres and was aware of Newton's shell theorem. Additionally, charging dielectric spheres uniformly presents challenges compared to conductive spheres. The conversation raises a hypothetical scenario about the implications of Coulomb's law when point charges are at zero distance apart, highlighting the complexities of electric force calculations.