Effects of Cooling & Metabolic Inhibitors on Urine Production

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The discussion centers on how urine production would be affected by cooling and metabolic inhibitors in the proximal convoluted tubules. Cooling and metabolic inhibitors can disrupt enzyme function, leading to reduced ATP production. Since the reabsorption of water in the proximal convoluted tubules relies on active transport mechanisms, a decrease in ATP results in less water being reabsorbed. Consequently, this leads to an increase in urine production. The importance of understanding the underlying mechanisms of active transport is emphasized, as it is crucial for accurately answering related questions.
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How would the volume of the urine production be altered if the proximal convulated tubules were experimentally subjected to
1)Cooling
2)metabolic inhibitors

Explain why as well?

Aby thoughts guys.Any help would highly be appriciated
 
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Hint: is it an active or a passive transport mechanism? Always understand how things work and THEN attempt to answer homework questions ;) we don't answer them for you, but we will help.
 
It is active transport.Cooling or metabolic inhibitors might denature or hinder the functioning of the enzyme which means less production of ATP.As there is less atp ,not a lot of water is reabsorbed.so urine production increases.
can u comment on my answer please.btw thanks for the quick reply.
 

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