To calculate the speed of an alpha particle with a charge of +2e and mass of 6.64 x 10^-27 kg, given its kinetic energy of 5.53 MeV, one must first convert the kinetic energy into joules. The speed can be determined using the classical kinetic energy formula, KE = 0.5mv^2, unless the particle's speed approaches a significant fraction of the speed of light, in which case relativistic effects must be considered. The discussion emphasizes the importance of showing working steps to clarify the calculation process. Participants are encouraged to confirm whether relativistic equations are necessary for accurate results. The conversation focuses on the methods to approach the problem effectively.