The discussion centers on the limitations of using electrodynamics to predict chemical reactions, specifically the formation of compounds like sodium chloride from sodium and chlorine. It highlights that while the ratio of elements in a compound can be determined experimentally, the sheer number of atoms involved in reactions complicates predictions based solely on physical properties. Quantum mechanics is mentioned as a framework that can explain atomic interactions and bonding through overlapping wave functions. The conversation emphasizes the complexity of calculating reactions involving vast quantities of atoms, making empirical methods necessary. Ultimately, the challenge lies in the practical application of theoretical physics to real-world chemical reactions.