The discussion revolves around a mathematical problem involving 25 large empty boxes, which are filled with medium and small boxes, ultimately totaling 291 boxes. Participants explore how to define variables for empty and total boxes, leading to the formulation of equations to calculate the number of empty boxes. The key invariant discussed is the relationship between total boxes and empty boxes, expressed as t - e = L + M, where L and M represent filled large and medium boxes, respectively. Through trial and error, the solution reveals that there are 253 empty boxes in total. The conversation emphasizes understanding the invariant and the relationships between the variables to solve the problem effectively.