DNA, RNA, and proteins interact through various binding mechanisms despite their structural differences. DNA and RNA are composed of nucleotides, while proteins consist of amino acids. Proteins can bind to nucleic acids by inserting helices into the major grooves of DNA, allowing amino acid residues to recognize specific bases via hydrogen bonding. Additionally, proteins can interact with the negatively charged sugar-phosphate backbone of nucleic acids through positively charged amino acids. Other interaction types include pi-pi stacking and cation-pi interactions. The discussion emphasizes the importance of prior research before asking questions in forums, as it fosters self-learning and prevents vague inquiries that may waste participants' time.