The Rational Root Theorem should be your first idea for a question such as this. What it does is test for easy roots that could help you reduce your higher degree polynomial into quadratics (at least in homework problems that's what usually happens).
Let's take a cubic equation as a case in point. What follows applies to all polynomials, but an example with a cubic is easier. You will find that we can factor our cubic as follows:
a_3x^3 + a_2x^2 + a_1x + a_0 = (qx - p)(b_2x^2 + b_1x + b_0)
where constants b0 through b2 are unknown.
Now, it is clear that if qx - p = 0, then the cubic equals 0. Thus, x = p/q is a root of the cubic--if we plug it into the cubic, we get 0. It is also clear from the factorization that a3x3 = qb2x3, thus q is a factor of a3. We also notice that a0 = -pb0, so p is a factor of a0.
Now, it is not guaranteed that q and p be factors of the leading and constant terms, because they may be irrational, in which case b2 and b0 are also irrational. However, if the cubic equation has a rational zero p/q, then p and q must be factors of a0 and a3. In general, for any polynomial which has a rational root p/q, p must be a factor of the constant term, and q must be a factor of the leading term.
This is the Rational Root Test. You try to find a easy, rational root of the cubic. Then you can use synthetic or long division to reduce the cubic to a quadratic.
Now, this means if you have the cubic equation ax3 + bx2 + cx + d, any rational root p/q will have \pm p divide d and \pm q divide a. Thus, you should try various \pm p/q into the cubic to see if you get a zero. If so, you have found a rational root, and you know that qx - p is a factor. You can use division to find the quadratic that is left.