Squeezing a toothpaste tube applies force that increases pressure inside, causing the toothpaste to move out of the tube regardless of its orientation. The pressure acts equally in all directions, pushing the toothpaste down and out when there is an opening. Fluids, including toothpaste, maintain constant volume under pressure, meaning they don't expand but rather move to areas of lower pressure. The movement of particles within the fluid is influenced by electromagnetic forces between atoms. Understanding these principles helps clarify the behavior of fluids under pressure, as illustrated by Pascal's principle.