Günter Blobel: Nobel Prize Winner & Cell Biology Pioneer

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Günter Blobel won the Nobel Prize in Medicine in 1999 for his groundbreaking research on cellular zip code tags, which are sequences of amino acids in proteins that determine their destination within the internal compartments of eukaryotic cells. This discovery is fundamental to understanding the complexity of eukaryotic cells, including those of plants, animals, fungi, and protozoans. The system of protein sorting likely originated with the earliest eukaryotic cells or their ancestors, highlighting Blobel's significant contribution to cell biology and the mechanisms that maintain cellular organization. Further details about his work and its implications can be found in related articles and resources.
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Won the Nobel Prize in Medicine in 1999 for his work on cellular zip code tags (a sequence of amino acids) in proteins that directed where each of the labeled proteins went, within the complex internal compartments of Eukaryotic cells.
Here is a NY Times story on him.

This is very basic eukaryotic cell biology that reveals a major component of how the complexity of eukarotic (plants, animal, and fungi (and also protozoans)) cells is created and maintained.
This system probably arose with the first eukarotic cells or their progenitors.
 
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