I did a search of autoplay.exe in "my pc", only thing came up were the two autoplay in the photoshop 6.0 installation folder ( which is just a copy of the CD on the desktop). There are no autoplay.exe in the computer.You need to find the directory that autoplay.exe is located and try running it from there. As posted earlier, some 32 bit programs use a 16 bit installer (most of these from back in the days of Win 9X or legacy install programs from those days that were not updated), which won't run on a 64 bit version of Windows. Also as posted, you could use the virtual PC Win XP mode for programs that use a 16 bit installer. I recommend using a USB stick to transfer files between the virtual XP machine and your actual machine. The virtual machine CPU speeds are OK, but the emulated graphics is slow (if it's still the S3 Trio emulation, it doesn't have any 3d acceleration, only 2d).
For applications and games that use cd/dvd copy protection programs like safedisk or securerom, these won't run on Windows 10 (even in virtual PC / XP mode), because Windows 10 won't allow those programs to install the drivers those programs use. Windows XP allows such drivers to be installed by default. Windows 7 and 8 default to not installing such drivers, but in the case of Windows 7 or 8, that can be overridden and the drivers installed. In the case of Windows 10, there's no documented method for forcing such drivers to install, as installing these type of drivers is considered a security risk.
You have file extensions turned off. Which means you likely have hide system files activated as well.
ThanksYou have file extensions turned off. Which means you likely have hide system files activated as well.
It's possible that setup.exe is hidden. It's also possible it's in a different directory (say, the AUTOPLAY directory there).
(Just Google 'view hidden files win 10')
Open autoplay/autorun in Notepad to see what file(s) it runs.