Mass can be converted into energy through the principle of mass defect, where binding energy is released when particles are separated. While mass itself can be viewed as a form of energy, the transformation between different energy types adheres to the conservation of energy principle. When particles like protons and neutrons are separated, their binding energy can result in an increase in mass, illustrating the reversible nature of these conversions. The discussion also touches on how energy can be converted into mass, as seen in particle creation at accelerators. Overall, the relationship between mass and energy is complex but fundamentally interconnected in physics.