To calculate the final speed of a block on an inclined plane, it's essential to consider both kinetic and potential energy, along with the work done against friction. A free body diagram helps identify the forces acting on the block, and a suitable coordinate system should be established. Newton's second law can be applied, with the equation W_nc = ΔK + ΔU guiding the calculations. The acceleration can be determined using a = g*sin(θ), factoring in friction to find the net force and adjusted acceleration. Ultimately, energy conservation principles can also be utilized to relate potential energy to kinetic energy and work done against friction for accurate speed calculations.