If two particles are interacting with one another, they can in principle become entangled, though that would depend on the nature of the interaction.
Similarly, interaction can destroy entanglement as well (the Schrodinger equation is time-symmetric).
It is even possible for two particles to interact in such a way that they entangle and disentangle over and over again.
This can be accomplished by say, a pair of spin-1/2 particles magnetically coupled to each other.
If two independent particles don't interact with each other, there is no way for them to become entangled, unless they can interact with a separate pair of already entangled particles.
Ultimately, the creation of the original entanglement requires interaction.
If two particles become entangled, and then no longer interact with each other or anything else, they stay entangled, even if they travel very far apart.
Indeed, the amount of entanglement would be exactly the same as it was just as the interaction stopped.
Interaction with a third party need not destroy entanglement (as Dr Chinese points out), but the more either particle becomes entangled with the "environment", the less the particles can be entangled with each other.
This is known as the monogamy of entanglement.