A fixed supply voltage of 110 volts DC can theoretically power 27 LEDs at 20 mA each, using a 1500 ohm resistor to account for voltage drop. The resistor must handle 0.55W, so a 1-watt resistor is recommended for safety. It's crucial to consider that not all LEDs will have the same voltage drop, which can lead to variations in brightness. Additionally, using a single series string at high voltage poses safety risks, and alternatives like multiple strings at lower voltages may be safer. Current limiting devices or switching LED drivers can provide better control over LED performance.