To calculate the work needed to separate an electron from a proton by 0.1 meters, one must consider the changing electric force between the charges as they are moved apart. The relationship between work and potential energy is crucial, as the work done is equal to the change in potential energy in this context. The initial and final separation distances are necessary for an accurate calculation, and the problem can be approached using energy considerations rather than direct force calculations. Understanding the concepts of electric potential and potential energy is essential for solving this problem effectively. The discussion emphasizes the importance of grasping the underlying principles rather than merely applying formulas.